Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study
Background Differentiating between bacterial and nonbacterial colitis remains a challenge. We aimed to evaluate the value of serum procalcitonin (PCT) and C-reactive protein (CRP) in differentiating between bacterial and nonbacterial colitis. Methods Adult patients with three or more episodes of wat...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Yeungnam University College of Medicine, Yeungnam University Institute Medical Science
2023-10-01
|
| Series: | Journal of Yeungnam Medical Science |
| Subjects: | |
| Online Access: | http://www.e-jyms.org/upload/pdf/jyms-2023-00059.pdf |
| _version_ | 1797644628417052672 |
|---|---|
| author | Jae Yong Lee So Yeon Lee Yoo Jin Lee Jin Wook Lee Jeong Seok Kim Ju Yup Lee Byoung Kuk Jang Woo Jin Chung Kwang Bum Cho Jae Seok Hwang |
| author_facet | Jae Yong Lee So Yeon Lee Yoo Jin Lee Jin Wook Lee Jeong Seok Kim Ju Yup Lee Byoung Kuk Jang Woo Jin Chung Kwang Bum Cho Jae Seok Hwang |
| author_sort | Jae Yong Lee |
| collection | DOAJ |
| description | Background Differentiating between bacterial and nonbacterial colitis remains a challenge. We aimed to evaluate the value of serum procalcitonin (PCT) and C-reactive protein (CRP) in differentiating between bacterial and nonbacterial colitis. Methods Adult patients with three or more episodes of watery diarrhea and colitis symptoms within 14 days of a hospital visit were eligible for this study. The patients’ stool pathogen polymerase chain reaction (PCR) testing results, serum PCT levels, and serum CRP levels were analyzed retrospectively. Patients were divided into bacterial and nonbacterial colitis groups according to their PCR. The laboratory data were compared between the two groups. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. Results In total, 636 patients were included; 186 in the bacterial colitis group and 450 in the nonbacterial colitis group. In the bacterial colitis group, Clostridium perfringens was the commonest pathogen (n=70), followed by Clostridium difficile toxin B (n=60). The AUC for PCT and CRP was 0.557 and 0.567, respectively, indicating poor discrimination. The sensitivity and specificity for diagnosing bacterial colitis were 54.8% and 52.6% for PCT, and 52.2% and 54.2% for CRP, respectively. Combining PCT and CRP measurements did not increase the discrimination performance (AUC, 0.522; 95% confidence interval, 0.474–0.571). Conclusion Neither PCT nor CRP helped discriminate bacterial colitis from nonbacterial colitis. |
| first_indexed | 2024-03-11T14:34:03Z |
| format | Article |
| id | doaj.art-2723bfa63ddb48afbf539806340a9ce6 |
| institution | Directory Open Access Journal |
| issn | 2799-8010 |
| language | English |
| last_indexed | 2024-03-11T14:34:03Z |
| publishDate | 2023-10-01 |
| publisher | Yeungnam University College of Medicine, Yeungnam University Institute Medical Science |
| record_format | Article |
| series | Journal of Yeungnam Medical Science |
| spelling | doaj.art-2723bfa63ddb48afbf539806340a9ce62023-10-31T05:42:23ZengYeungnam University College of Medicine, Yeungnam University Institute Medical ScienceJournal of Yeungnam Medical Science2799-80102023-10-0140438839310.12701/jyms.2023.000592775Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective studyJae Yong Lee0So Yeon Lee1Yoo Jin LeeJin Wook Lee2Jeong Seok Kim3Ju Yup Lee4Byoung Kuk Jang5Woo Jin Chung6Kwang Bum Cho7Jae Seok Hwang8 Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, KoreaBackground Differentiating between bacterial and nonbacterial colitis remains a challenge. We aimed to evaluate the value of serum procalcitonin (PCT) and C-reactive protein (CRP) in differentiating between bacterial and nonbacterial colitis. Methods Adult patients with three or more episodes of watery diarrhea and colitis symptoms within 14 days of a hospital visit were eligible for this study. The patients’ stool pathogen polymerase chain reaction (PCR) testing results, serum PCT levels, and serum CRP levels were analyzed retrospectively. Patients were divided into bacterial and nonbacterial colitis groups according to their PCR. The laboratory data were compared between the two groups. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. Results In total, 636 patients were included; 186 in the bacterial colitis group and 450 in the nonbacterial colitis group. In the bacterial colitis group, Clostridium perfringens was the commonest pathogen (n=70), followed by Clostridium difficile toxin B (n=60). The AUC for PCT and CRP was 0.557 and 0.567, respectively, indicating poor discrimination. The sensitivity and specificity for diagnosing bacterial colitis were 54.8% and 52.6% for PCT, and 52.2% and 54.2% for CRP, respectively. Combining PCT and CRP measurements did not increase the discrimination performance (AUC, 0.522; 95% confidence interval, 0.474–0.571). Conclusion Neither PCT nor CRP helped discriminate bacterial colitis from nonbacterial colitis.http://www.e-jyms.org/upload/pdf/jyms-2023-00059.pdfdifferential diagnosisdysenteryinfectionsprocalcitonin |
| spellingShingle | Jae Yong Lee So Yeon Lee Yoo Jin Lee Jin Wook Lee Jeong Seok Kim Ju Yup Lee Byoung Kuk Jang Woo Jin Chung Kwang Bum Cho Jae Seok Hwang Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study Journal of Yeungnam Medical Science differential diagnosis dysentery infections procalcitonin |
| title | Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study |
| title_full | Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study |
| title_fullStr | Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study |
| title_full_unstemmed | Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study |
| title_short | Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study |
| title_sort | diagnostic value of serum procalcitonin and c reactive protein in discriminating between bacterial and nonbacterial colitis a retrospective study |
| topic | differential diagnosis dysentery infections procalcitonin |
| url | http://www.e-jyms.org/upload/pdf/jyms-2023-00059.pdf |
| work_keys_str_mv | AT jaeyonglee diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT soyeonlee diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT yoojinlee diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT jinwooklee diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT jeongseokkim diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT juyuplee diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT byoungkukjang diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT woojinchung diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT kwangbumcho diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy AT jaeseokhwang diagnosticvalueofserumprocalcitoninandcreactiveproteinindiscriminatingbetweenbacterialandnonbacterialcolitisaretrospectivestudy |