Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE Pathogens
The ESKAPE pathogens, including bacteria such as <i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> spe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/10/1556 |
| _version_ | 1827721951798362112 |
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| author | Marco Artini Rosanna Papa Gianluca Vrenna Marika Trecca Irene Paris Caterina D’Angelo Maria Luisa Tutino Ermenegilda Parrilli Laura Selan |
| author_facet | Marco Artini Rosanna Papa Gianluca Vrenna Marika Trecca Irene Paris Caterina D’Angelo Maria Luisa Tutino Ermenegilda Parrilli Laura Selan |
| author_sort | Marco Artini |
| collection | DOAJ |
| description | The ESKAPE pathogens, including bacteria such as <i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> species, pose a global health threat due to their ability to resist antimicrobial drugs and evade the immune system. These pathogens are responsible for hospital-acquired infections, especially in intensive care units, and contribute to the growing problem of multi-drug resistance. In this study, researchers focused on exploring the potential of Antarctic marine bacteria as a source of anti-biofilm molecules to combat ESKAPE pathogens. Four Antarctic bacterial strains were selected, and their cell-free supernatants were tested against 60 clinical ESKAPE isolates. The results showed that the supernatants did not exhibit antimicrobial activity but effectively prevented biofilm formation and dispersed mature biofilms. This research highlights the promising potential of Antarctic bacteria in producing compounds that can counteract biofilms formed by clinically significant bacterial species. These findings contribute to the development of new strategies for preventing and controlling infections caused by ESKAPE pathogens. |
| first_indexed | 2024-03-10T21:29:07Z |
| format | Article |
| id | doaj.art-272439afb8ac437292f5f5ced5f341ca |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T21:29:07Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-272439afb8ac437292f5f5ced5f341ca2023-11-19T15:27:09ZengMDPI AGAntibiotics2079-63822023-10-011210155610.3390/antibiotics12101556Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE PathogensMarco Artini0Rosanna Papa1Gianluca Vrenna2Marika Trecca3Irene Paris4Caterina D’Angelo5Maria Luisa Tutino6Ermenegilda Parrilli7Laura Selan8Department of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Chemical Sciences, Federico II University, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, ItalyDepartment of Chemical Sciences, Federico II University, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, ItalyDepartment of Chemical Sciences, Federico II University, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, ItalyThe ESKAPE pathogens, including bacteria such as <i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> species, pose a global health threat due to their ability to resist antimicrobial drugs and evade the immune system. These pathogens are responsible for hospital-acquired infections, especially in intensive care units, and contribute to the growing problem of multi-drug resistance. In this study, researchers focused on exploring the potential of Antarctic marine bacteria as a source of anti-biofilm molecules to combat ESKAPE pathogens. Four Antarctic bacterial strains were selected, and their cell-free supernatants were tested against 60 clinical ESKAPE isolates. The results showed that the supernatants did not exhibit antimicrobial activity but effectively prevented biofilm formation and dispersed mature biofilms. This research highlights the promising potential of Antarctic bacteria in producing compounds that can counteract biofilms formed by clinically significant bacterial species. These findings contribute to the development of new strategies for preventing and controlling infections caused by ESKAPE pathogens.https://www.mdpi.com/2079-6382/12/10/1556<i>Enterococcus faecium</i><i>Staphylococcus aureus</i><i>Klebsiella pneumoniae</i><i>Acinetobacter baumannii</i><i>Pseudomonas aeruginosa</i><i>Enterobacter</i> sp. |
| spellingShingle | Marco Artini Rosanna Papa Gianluca Vrenna Marika Trecca Irene Paris Caterina D’Angelo Maria Luisa Tutino Ermenegilda Parrilli Laura Selan Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE Pathogens Antibiotics <i>Enterococcus faecium</i> <i>Staphylococcus aureus</i> <i>Klebsiella pneumoniae</i> <i>Acinetobacter baumannii</i> <i>Pseudomonas aeruginosa</i> <i>Enterobacter</i> sp. |
| title | Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE Pathogens |
| title_full | Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE Pathogens |
| title_fullStr | Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE Pathogens |
| title_full_unstemmed | Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE Pathogens |
| title_short | Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE Pathogens |
| title_sort | antarctic marine bacteria as a source of anti biofilm molecules to combat eskape pathogens |
| topic | <i>Enterococcus faecium</i> <i>Staphylococcus aureus</i> <i>Klebsiella pneumoniae</i> <i>Acinetobacter baumannii</i> <i>Pseudomonas aeruginosa</i> <i>Enterobacter</i> sp. |
| url | https://www.mdpi.com/2079-6382/12/10/1556 |
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