4’4 Bromophenyl 4’Piperidinol Derivatives as a Multifactorial Anti-Alzheimer Agent: Synthesis, In-Vitro, and In-Silico Based Studies

4’4 Bromophenyl 4’Piperidinol Derivatives as a Multifactorial Anti-Alzheimer Agent: Synthesis, In-Vitro, and In-Silico Based Studies

4’4 bromophenyl 4’piperidinol derivatives were synthesized, and evaluated as multifactorial agents for the treatment of Alzheimer’s disease (AD). Among all the analogues, AB11 and AB14 showed the best activity against acetylcholinesterase (AChE) with IC<sub>50</sub> = 0.029 μM and 0.038...

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Bibliographic Details
Main Authors: Syeda Abiha Rizvi, Nousheen Mushtaq, Ahsaan Ahmad, Laila Anwer, Saira Asghar, Mariam Arefa, Anam Zehra, Madiha Arif, Farah Batool
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Medical Sciences Forum
Subjects:
4’4 bromophenyl 4’piperidinol
Alzheimer’s disease (AD)
acetylcholinesterase
molecular modeling
monoamine oxidase (MAO)
antioxidant
Online Access:https://www.mdpi.com/2673-9992/14/1/80

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