Evaluating the beneficial and detrimental effects of bile pigments in early and later life
The heme degradation pathway has been conserved throughout phylogeny and allows for the removal of a pro-oxidant and the generation of unique molecules including bile pigment with important cellular functions. The impact of bile pigments on health and disease are reviewed as is the special circumst...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00115/full |
| _version_ | 1819364803440803840 |
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| author | Phyllis A. Dennery |
| author_facet | Phyllis A. Dennery |
| author_sort | Phyllis A. Dennery |
| collection | DOAJ |
| description | The heme degradation pathway has been conserved throughout phylogeny and allows for the removal of a pro-oxidant and the generation of unique molecules including bile pigment with important cellular functions. The impact of bile pigments on health and disease are reviewed as is the special circumstance of neonatal hyperbilirubinemia. In addition, the importance of promoter polymorphisms in the UDP-glucuronyltransferase gene (UGTA1), which is key to the elimination of excess bilirubin and to preventing its toxicity, are discussed. Overall, the duality of bile pigments as either cytoprotective or toxic molecules is highlighted. |
| first_indexed | 2024-12-24T23:04:45Z |
| format | Article |
| id | doaj.art-2726b67100054c1c82a03389ae43a9cd |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-24T23:04:45Z |
| publishDate | 2012-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2726b67100054c1c82a03389ae43a9cd2022-12-21T16:35:02ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122012-06-01310.3389/fphar.2012.0011527212Evaluating the beneficial and detrimental effects of bile pigments in early and later lifePhyllis A. Dennery0University of Pennsylvania School of MedicineThe heme degradation pathway has been conserved throughout phylogeny and allows for the removal of a pro-oxidant and the generation of unique molecules including bile pigment with important cellular functions. The impact of bile pigments on health and disease are reviewed as is the special circumstance of neonatal hyperbilirubinemia. In addition, the importance of promoter polymorphisms in the UDP-glucuronyltransferase gene (UGTA1), which is key to the elimination of excess bilirubin and to preventing its toxicity, are discussed. Overall, the duality of bile pigments as either cytoprotective or toxic molecules is highlighted.http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00115/fullKernicterusneonatal jaundiceUDP-glucuronyltranantioxidantpolymorphisms |
| spellingShingle | Phyllis A. Dennery Evaluating the beneficial and detrimental effects of bile pigments in early and later life Frontiers in Pharmacology Kernicterus neonatal jaundice UDP-glucuronyltran antioxidant polymorphisms |
| title | Evaluating the beneficial and detrimental effects of bile pigments in early and later life |
| title_full | Evaluating the beneficial and detrimental effects of bile pigments in early and later life |
| title_fullStr | Evaluating the beneficial and detrimental effects of bile pigments in early and later life |
| title_full_unstemmed | Evaluating the beneficial and detrimental effects of bile pigments in early and later life |
| title_short | Evaluating the beneficial and detrimental effects of bile pigments in early and later life |
| title_sort | evaluating the beneficial and detrimental effects of bile pigments in early and later life |
| topic | Kernicterus neonatal jaundice UDP-glucuronyltran antioxidant polymorphisms |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00115/full |
| work_keys_str_mv | AT phyllisadennery evaluatingthebeneficialanddetrimentaleffectsofbilepigmentsinearlyandlaterlife |