Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan
Background: The incidence of HPV positive oropharyngeal cancer is increasing in Taiwan. Given this, it is critical to understand the prevalence of oral HPV infection since this cancer is potentially preventable. A community-based study was conducted to evaluate the prevalence of oral HPV infection a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-01-01
|
| Series: | Journal of the Formosan Medical Association |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664617306307 |
| _version_ | 1828395594019766272 |
|---|---|
| author | Cheng-Ping Wang Tseng-Cheng Chen Hao-Hui Chen Wan-Lun Hsu Yih-Leong Chang |
| author_facet | Cheng-Ping Wang Tseng-Cheng Chen Hao-Hui Chen Wan-Lun Hsu Yih-Leong Chang |
| author_sort | Cheng-Ping Wang |
| collection | DOAJ |
| description | Background: The incidence of HPV positive oropharyngeal cancer is increasing in Taiwan. Given this, it is critical to understand the prevalence of oral HPV infection since this cancer is potentially preventable. A community-based study was conducted to evaluate the prevalence of oral HPV infection and sexual behavior changes. Methods: Between January and December 2016, 100 subjects between 20 and 70 years-old with current/ever betel nut chewing or current cigarette smoking visited the Department of Health, New Taipei City. Subjects with cancer history or known HIV/AIDS were excluded. Sexual behavior information was collected through a questionnaire. Oral rinse samples and oropharyngeal swabs were obtained for HPV genotyping using the EasyChip HPV genotyping array (King-Car, Taiwan). Results: 92 men and 8 women were recruited. The prevalence of oral HPV infection was 3%, present between 60 and 70 (11%) and between 30 and 40 years old (4%). The prevalence of the first sexual contact at younger than 20 years old were 71.4%, 53.6%, 15.4% and 44% in <40, 40–49, 50–59 and 60+ years old, respectively (p for trend = 0.0036). The prevalence of 3 or more lifetime sexual partners were 60.7%, 57.1%, 23.1% and 16.7%, respectively for <40, 40–49, 50–59 and 60+ years old (p for trend = 0.0005). Conclusion: The prevalence of oral HPV infection is 3%, in current/ever betel nut chewers or current cigarette smokers in Northern Taiwan. Younger generation have more lifetime sexual partners and younger first sexual contact. This could explain the rising incidence of HPV positive oropharyngeal cancer in Taiwan. Keywords: Human papillomavirus, Oropharyngeal cancer, Tongue base, Tonsil, Screening |
| first_indexed | 2024-12-10T08:15:52Z |
| format | Article |
| id | doaj.art-2727ccc5cf3b421ca15fd0718a609795 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-10T08:15:52Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-2727ccc5cf3b421ca15fd0718a6097952022-12-22T01:56:28ZengElsevierJournal of the Formosan Medical Association0929-66462019-01-011181203208Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern TaiwanCheng-Ping Wang0Tseng-Cheng Chen1Hao-Hui Chen2Wan-Lun Hsu3Yih-Leong Chang4Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Otolaryngology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Otolaryngology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, TaiwanGenomics Research Center, Academia Sinica, Taipei, TaiwanGraduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Department of Pathology, National Taiwan University Hospital, 7, Chung-Shan South Rd., Taipei, Taiwan. Fax: +886 2 23410905.Background: The incidence of HPV positive oropharyngeal cancer is increasing in Taiwan. Given this, it is critical to understand the prevalence of oral HPV infection since this cancer is potentially preventable. A community-based study was conducted to evaluate the prevalence of oral HPV infection and sexual behavior changes. Methods: Between January and December 2016, 100 subjects between 20 and 70 years-old with current/ever betel nut chewing or current cigarette smoking visited the Department of Health, New Taipei City. Subjects with cancer history or known HIV/AIDS were excluded. Sexual behavior information was collected through a questionnaire. Oral rinse samples and oropharyngeal swabs were obtained for HPV genotyping using the EasyChip HPV genotyping array (King-Car, Taiwan). Results: 92 men and 8 women were recruited. The prevalence of oral HPV infection was 3%, present between 60 and 70 (11%) and between 30 and 40 years old (4%). The prevalence of the first sexual contact at younger than 20 years old were 71.4%, 53.6%, 15.4% and 44% in <40, 40–49, 50–59 and 60+ years old, respectively (p for trend = 0.0036). The prevalence of 3 or more lifetime sexual partners were 60.7%, 57.1%, 23.1% and 16.7%, respectively for <40, 40–49, 50–59 and 60+ years old (p for trend = 0.0005). Conclusion: The prevalence of oral HPV infection is 3%, in current/ever betel nut chewers or current cigarette smokers in Northern Taiwan. Younger generation have more lifetime sexual partners and younger first sexual contact. This could explain the rising incidence of HPV positive oropharyngeal cancer in Taiwan. Keywords: Human papillomavirus, Oropharyngeal cancer, Tongue base, Tonsil, Screeninghttp://www.sciencedirect.com/science/article/pii/S0929664617306307 |
| spellingShingle | Cheng-Ping Wang Tseng-Cheng Chen Hao-Hui Chen Wan-Lun Hsu Yih-Leong Chang Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan Journal of the Formosan Medical Association |
| title | Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan |
| title_full | Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan |
| title_fullStr | Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan |
| title_full_unstemmed | Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan |
| title_short | Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan |
| title_sort | prevalence of current oral hpv infection among 100 betel nut chewers or cigarette smokers in northern taiwan |
| url | http://www.sciencedirect.com/science/article/pii/S0929664617306307 |
| work_keys_str_mv | AT chengpingwang prevalenceofcurrentoralhpvinfectionamong100betelnutchewersorcigarettesmokersinnortherntaiwan AT tsengchengchen prevalenceofcurrentoralhpvinfectionamong100betelnutchewersorcigarettesmokersinnortherntaiwan AT haohuichen prevalenceofcurrentoralhpvinfectionamong100betelnutchewersorcigarettesmokersinnortherntaiwan AT wanlunhsu prevalenceofcurrentoralhpvinfectionamong100betelnutchewersorcigarettesmokersinnortherntaiwan AT yihleongchang prevalenceofcurrentoralhpvinfectionamong100betelnutchewersorcigarettesmokersinnortherntaiwan |