Biomarkers of postoperative delirium and cognitive dysfunction
Elderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morb...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-06-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00112/full |
| _version_ | 1811280708518281216 |
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| author | Ganna eAndrosova Roland eKrause Georg eWinterer Reinhard eSchneider |
| author_facet | Ganna eAndrosova Roland eKrause Georg eWinterer Reinhard eSchneider |
| author_sort | Ganna eAndrosova |
| collection | DOAJ |
| description | Elderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers. |
| first_indexed | 2024-04-13T01:20:46Z |
| format | Article |
| id | doaj.art-272859db28544e309891990441f73b68 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T01:20:46Z |
| publishDate | 2015-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-272859db28544e309891990441f73b682022-12-22T03:08:47ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-06-01710.3389/fnagi.2015.00112134989Biomarkers of postoperative delirium and cognitive dysfunctionGanna eAndrosova0Roland eKrause1Georg eWinterer2Reinhard eSchneider3University of LuxembourgUniversity of LuxembourgCharité – University Medicine BerlinUniversity of LuxembourgElderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00112/fullSystems BiologybiomarkerPOCDpostoperative cognitive dysfunctionpostoperative deliriumPOD |
| spellingShingle | Ganna eAndrosova Roland eKrause Georg eWinterer Reinhard eSchneider Biomarkers of postoperative delirium and cognitive dysfunction Frontiers in Aging Neuroscience Systems Biology biomarker POCD postoperative cognitive dysfunction postoperative delirium POD |
| title | Biomarkers of postoperative delirium and cognitive dysfunction |
| title_full | Biomarkers of postoperative delirium and cognitive dysfunction |
| title_fullStr | Biomarkers of postoperative delirium and cognitive dysfunction |
| title_full_unstemmed | Biomarkers of postoperative delirium and cognitive dysfunction |
| title_short | Biomarkers of postoperative delirium and cognitive dysfunction |
| title_sort | biomarkers of postoperative delirium and cognitive dysfunction |
| topic | Systems Biology biomarker POCD postoperative cognitive dysfunction postoperative delirium POD |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00112/full |
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