Effect of NPC1L1 and HMGCR Genetic Variants With Premature Triple-Vessel Coronary Disease

Effect of NPC1L1 and HMGCR Genetic Variants With Premature Triple-Vessel Coronary Disease

Background: Both Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) play a key role on dyslipidaemia. We aim to evaluate whether NPC1L1 and HMGCR genetic variants are associated with susceptibility of premature triple-vessel disease (PTVD).Methods: Four singl...

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Bibliographic Details
Main Authors: Xueyan Zhao, Jingjing Xu, Xiaofang Tang, Keyong Huang, Jiawen Li, Ru Liu, Lin Jiang, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
NPC1L1
HMGCR
genetic variants
SYNTAX score
premature triple-vessel disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.704501/full

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