Allograft nephrectomy vs. no nephrectomy for failed renal transplants
The role of allograft nephrectomy (AN) in failed renal transplants is a topic of debate, owing to controversial results reported in the literature and the fact that most of the studies are limited by a retrospective design and small numbers of participants. Allograft nephrectomy is most likely of be...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nephrology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneph.2023.1169181/full |
| _version_ | 1827202452042022912 |
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| author | Michelle McDonald Michelle McDonald |
| author_facet | Michelle McDonald Michelle McDonald |
| author_sort | Michelle McDonald |
| collection | DOAJ |
| description | The role of allograft nephrectomy (AN) in failed renal transplants is a topic of debate, owing to controversial results reported in the literature and the fact that most of the studies are limited by a retrospective design and small numbers of participants. Allograft nephrectomy is most likely of benefit in the patient with recurrent allograft intolerance syndrome (AIS) following pulse steroids. Immunosuppression weaning in the presence of clinical signs related to a chronic inflammatory state is also reasonable grounds to pursue AN. Studies are mainly inconclusive but suggest that AN has no overall benefit for allograft survival after retransplant. This topic is still of interest in the transplant field and is particularly relevant for patients who are likely to require retransplantation within their lifetime. Further assessment is needed in the form of randomized controlled trials that control for various AN indications and immunosuppression regimens, and have clearly defined survival outcomes. |
| first_indexed | 2024-03-12T22:44:55Z |
| format | Article |
| id | doaj.art-27289a659a0d47c595dbaaead9fcf0a0 |
| institution | Directory Open Access Journal |
| issn | 2813-0626 |
| language | English |
| last_indexed | 2025-03-21T11:20:49Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nephrology |
| spelling | doaj.art-27289a659a0d47c595dbaaead9fcf0a02024-07-02T09:37:52ZengFrontiers Media S.A.Frontiers in Nephrology2813-06262023-07-01310.3389/fneph.2023.11691811169181Allograft nephrectomy vs. no nephrectomy for failed renal transplantsMichelle McDonald0Michelle McDonald1Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United StatesDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesThe role of allograft nephrectomy (AN) in failed renal transplants is a topic of debate, owing to controversial results reported in the literature and the fact that most of the studies are limited by a retrospective design and small numbers of participants. Allograft nephrectomy is most likely of benefit in the patient with recurrent allograft intolerance syndrome (AIS) following pulse steroids. Immunosuppression weaning in the presence of clinical signs related to a chronic inflammatory state is also reasonable grounds to pursue AN. Studies are mainly inconclusive but suggest that AN has no overall benefit for allograft survival after retransplant. This topic is still of interest in the transplant field and is particularly relevant for patients who are likely to require retransplantation within their lifetime. Further assessment is needed in the form of randomized controlled trials that control for various AN indications and immunosuppression regimens, and have clearly defined survival outcomes.https://www.frontiersin.org/articles/10.3389/fneph.2023.1169181/fullallograft nephrectomykidney transplantimmunosuppressionallograft intolerancefailure |
| spellingShingle | Michelle McDonald Michelle McDonald Allograft nephrectomy vs. no nephrectomy for failed renal transplants Frontiers in Nephrology allograft nephrectomy kidney transplant immunosuppression allograft intolerance failure |
| title | Allograft nephrectomy vs. no nephrectomy for failed renal transplants |
| title_full | Allograft nephrectomy vs. no nephrectomy for failed renal transplants |
| title_fullStr | Allograft nephrectomy vs. no nephrectomy for failed renal transplants |
| title_full_unstemmed | Allograft nephrectomy vs. no nephrectomy for failed renal transplants |
| title_short | Allograft nephrectomy vs. no nephrectomy for failed renal transplants |
| title_sort | allograft nephrectomy vs no nephrectomy for failed renal transplants |
| topic | allograft nephrectomy kidney transplant immunosuppression allograft intolerance failure |
| url | https://www.frontiersin.org/articles/10.3389/fneph.2023.1169181/full |
| work_keys_str_mv | AT michellemcdonald allograftnephrectomyvsnonephrectomyforfailedrenaltransplants AT michellemcdonald allograftnephrectomyvsnonephrectomyforfailedrenaltransplants |