N-octanoyl dopamine treatment of endothelial cells induces the unfolded protein response and results in hypometabolism and tolerance to hypothermia.

N-octanoyl dopamine treatment of endothelial cells induces the unfolded protein response and results in hypometabolism and tolerance to hypothermia.

N-acyl dopamines (NADD) are gaining attention in the field of inflammatory and neurological disorders. Due to their hydrophobicity, NADD may have access to the endoplasmic reticulum (ER). We therefore investigated if NADD induce the unfolded protein response (UPR) and if this in turn influences cell...

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Main Authors: Eleni Stamellou, Johann Fontana, Johannes Wedel, Emmanouil Ntasis, Carsten Sticht, Anja Becker, Prama Pallavi, Kerstin Wolf, Bernhard K Krämer, Mathias Hafner, Willem J van Son, Benito A Yard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4057113?pdf=render

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