Traditional Chinese medicine use in neuropathic pain: Targeting glial cell-mediated neuroinflammation
Introduction: Neuropathic pain (NP) is a common form of chronic pain that severely affects patients' physical and mental health. The pathogenesis of NP is complex, with peripheral and central sensitization as the main mechanisms. Neuroinflammation mediated by peripheral glial cells (Schwann cel...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142523001082 |
| _version_ | 1797388595415220224 |
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| author | Wulin Liang Mingqian Zhang Xiyan Huang Rikang Huang Jiahui Gao Zhanhong Jia Shuofeng Zhang |
| author_facet | Wulin Liang Mingqian Zhang Xiyan Huang Rikang Huang Jiahui Gao Zhanhong Jia Shuofeng Zhang |
| author_sort | Wulin Liang |
| collection | DOAJ |
| description | Introduction: Neuropathic pain (NP) is a common form of chronic pain that severely affects patients' physical and mental health. The pathogenesis of NP is complex, with peripheral and central sensitization as the main mechanisms. Neuroinflammation mediated by peripheral glial cells (Schwann cells and satellite glial cells) and central glial cells (microglia and astrocytes) is the main factor driving peripheral sensitization and central sensitization. Traditional Chinese medicine (TCM) can prevent and treat NP and is becoming a popular area of research for novel analgesics. However, the mechanism of TCM in treating NP by regulating glial cell-mediated neuroinflammation is unclear. Methods: Online databases, including Scopus, PubMed, and Web of Science, were searched using different keywords: “glial cells and neuropathic pain”, “traditional Chinese medicine and neuropathic pain”. The purpose of this review is to summarize the mechanism of TCM's anti-NP effect from the perspective of glial cell-mediated neuroinflammation. Results: Neuroinflammation mediated by glial cells promotes the occurrence and development of NP. TCM can inhibit inflammatory responses mediated by glial cells mainly through inhibition of purinergic signaling, the MAPK pathway, the TLR pathway, the NF-κB pathway, and chemokine signaling, thereby alleviating NP. Discussion: TCM is a valuable candidate for the treatment of NP. This review will provide a reference for further scientific development and application of anti-NP therapeutic drugs. |
| first_indexed | 2024-03-08T22:43:02Z |
| format | Article |
| id | doaj.art-272a5b1ca3a94809bed00991ba3d51bf |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-03-08T22:43:02Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-272a5b1ca3a94809bed00991ba3d51bf2023-12-17T06:42:58ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252023-12-019100322Traditional Chinese medicine use in neuropathic pain: Targeting glial cell-mediated neuroinflammationWulin Liang0Mingqian Zhang1Xiyan Huang2Rikang Huang3Jiahui Gao4Zhanhong Jia5Shuofeng Zhang6School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaCorresponding authors.; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaCorresponding authors.; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaIntroduction: Neuropathic pain (NP) is a common form of chronic pain that severely affects patients' physical and mental health. The pathogenesis of NP is complex, with peripheral and central sensitization as the main mechanisms. Neuroinflammation mediated by peripheral glial cells (Schwann cells and satellite glial cells) and central glial cells (microglia and astrocytes) is the main factor driving peripheral sensitization and central sensitization. Traditional Chinese medicine (TCM) can prevent and treat NP and is becoming a popular area of research for novel analgesics. However, the mechanism of TCM in treating NP by regulating glial cell-mediated neuroinflammation is unclear. Methods: Online databases, including Scopus, PubMed, and Web of Science, were searched using different keywords: “glial cells and neuropathic pain”, “traditional Chinese medicine and neuropathic pain”. The purpose of this review is to summarize the mechanism of TCM's anti-NP effect from the perspective of glial cell-mediated neuroinflammation. Results: Neuroinflammation mediated by glial cells promotes the occurrence and development of NP. TCM can inhibit inflammatory responses mediated by glial cells mainly through inhibition of purinergic signaling, the MAPK pathway, the TLR pathway, the NF-κB pathway, and chemokine signaling, thereby alleviating NP. Discussion: TCM is a valuable candidate for the treatment of NP. This review will provide a reference for further scientific development and application of anti-NP therapeutic drugs.http://www.sciencedirect.com/science/article/pii/S2667142523001082Neuropathic painGlial cellsNeuroinflammationTraditional Chinese medicineMechanisms |
| spellingShingle | Wulin Liang Mingqian Zhang Xiyan Huang Rikang Huang Jiahui Gao Zhanhong Jia Shuofeng Zhang Traditional Chinese medicine use in neuropathic pain: Targeting glial cell-mediated neuroinflammation Pharmacological Research - Modern Chinese Medicine Neuropathic pain Glial cells Neuroinflammation Traditional Chinese medicine Mechanisms |
| title | Traditional Chinese medicine use in neuropathic pain: Targeting glial cell-mediated neuroinflammation |
| title_full | Traditional Chinese medicine use in neuropathic pain: Targeting glial cell-mediated neuroinflammation |
| title_fullStr | Traditional Chinese medicine use in neuropathic pain: Targeting glial cell-mediated neuroinflammation |
| title_full_unstemmed | Traditional Chinese medicine use in neuropathic pain: Targeting glial cell-mediated neuroinflammation |
| title_short | Traditional Chinese medicine use in neuropathic pain: Targeting glial cell-mediated neuroinflammation |
| title_sort | traditional chinese medicine use in neuropathic pain targeting glial cell mediated neuroinflammation |
| topic | Neuropathic pain Glial cells Neuroinflammation Traditional Chinese medicine Mechanisms |
| url | http://www.sciencedirect.com/science/article/pii/S2667142523001082 |
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