From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior
The investigation of GABAergic inhibitory circuits has substantially expanded over the past few years. The development of new tools and technology has allowed investigators to classify many diverse groups of inhibitory neurons by several delineating factors: these include their connectivity motifs,...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-07-01
|
| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnmol.2019.00168/full |
| _version_ | 1818259537937825792 |
|---|---|
| author | Olivia K. Swanson Olivia K. Swanson Arianna Maffei Arianna Maffei |
| author_facet | Olivia K. Swanson Olivia K. Swanson Arianna Maffei Arianna Maffei |
| author_sort | Olivia K. Swanson |
| collection | DOAJ |
| description | The investigation of GABAergic inhibitory circuits has substantially expanded over the past few years. The development of new tools and technology has allowed investigators to classify many diverse groups of inhibitory neurons by several delineating factors: these include their connectivity motifs, expression of specific molecular markers, receptor diversity, and ultimately their role in brain function. Despite this progress, however, there is still limited understanding of how GABAergic neurons are recruited by their input and how their activity is modulated by behavioral states. This limitation is primarily due to the fact that studies of GABAergic inhibition are mainly geared toward determining how, once activated, inhibitory circuits regulate the activity of excitatory neurons. In this review article, we will outline recent work investigating the anatomical and physiological properties of inputs that activate cortical GABAergic neurons, and discuss how these inhibitory cells are differentially recruited during behavior. |
| first_indexed | 2024-12-12T18:17:01Z |
| format | Article |
| id | doaj.art-272b5af462ab4186895d7033354318e9 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-12T18:17:01Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-272b5af462ab4186895d7033354318e92022-12-22T00:16:15ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992019-07-011210.3389/fnmol.2019.00168468789From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in BehaviorOlivia K. Swanson0Olivia K. Swanson1Arianna Maffei2Arianna Maffei3Department of Neurobiology and Behavior, SUNY—Stony Brook, Stony Brook, NY, United StatesGraduate Program in Neuroscience, SUNY—Stony Brook, Stony Brook, NY, United StatesDepartment of Neurobiology and Behavior, SUNY—Stony Brook, Stony Brook, NY, United StatesGraduate Program in Neuroscience, SUNY—Stony Brook, Stony Brook, NY, United StatesThe investigation of GABAergic inhibitory circuits has substantially expanded over the past few years. The development of new tools and technology has allowed investigators to classify many diverse groups of inhibitory neurons by several delineating factors: these include their connectivity motifs, expression of specific molecular markers, receptor diversity, and ultimately their role in brain function. Despite this progress, however, there is still limited understanding of how GABAergic neurons are recruited by their input and how their activity is modulated by behavioral states. This limitation is primarily due to the fact that studies of GABAergic inhibition are mainly geared toward determining how, once activated, inhibitory circuits regulate the activity of excitatory neurons. In this review article, we will outline recent work investigating the anatomical and physiological properties of inputs that activate cortical GABAergic neurons, and discuss how these inhibitory cells are differentially recruited during behavior.https://www.frontiersin.org/article/10.3389/fnmol.2019.00168/fullGABAsynapsescircuitexcitabilityplasticity |
| spellingShingle | Olivia K. Swanson Olivia K. Swanson Arianna Maffei Arianna Maffei From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior Frontiers in Molecular Neuroscience GABA synapses circuit excitability plasticity |
| title | From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior |
| title_full | From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior |
| title_fullStr | From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior |
| title_full_unstemmed | From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior |
| title_short | From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior |
| title_sort | from hiring to firing activation of inhibitory neurons and their recruitment in behavior |
| topic | GABA synapses circuit excitability plasticity |
| url | https://www.frontiersin.org/article/10.3389/fnmol.2019.00168/full |
| work_keys_str_mv | AT oliviakswanson fromhiringtofiringactivationofinhibitoryneuronsandtheirrecruitmentinbehavior AT oliviakswanson fromhiringtofiringactivationofinhibitoryneuronsandtheirrecruitmentinbehavior AT ariannamaffei fromhiringtofiringactivationofinhibitoryneuronsandtheirrecruitmentinbehavior AT ariannamaffei fromhiringtofiringactivationofinhibitoryneuronsandtheirrecruitmentinbehavior |