Sustained heterologous gene expression in pancreatic islet organoids using adeno-associated virus serotype 8

Sustained heterologous gene expression in pancreatic islet organoids using adeno-associated virus serotype 8

Genetic modification of pancreatic islet organoids, assembled in vitro prior to transplantation is an emerging alternative to direct in vivo genetic manipulations for a number of clinical and research applications. We have previously shown that dispersion of islet cells followed by re-aggregation in...

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Bibliographic Details
Main Authors: Anna Voznesenskaya, Per-Olof Berggren, Erwin Ilegems
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
pseudoislet
AAV
adenovirus
gene therapy
delta cells
diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1147244/full

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