Development of the thermophilic fungus Myceliophthora thermophila into glucoamylase hyperproduction system via the metabolic engineering using improved AsCas12a variants

Development of the thermophilic fungus Myceliophthora thermophila into glucoamylase hyperproduction system via the metabolic engineering using improved AsCas12a variants

Abstract Background Glucoamylase is an important enzyme for starch saccharification in the food and biofuel industries and mainly produced from mesophilic fungi such as Aspergillus and Rhizopus species. Enzymes produced from thermophilic fungi can save the fermentation energy and reduce costs as com...

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Bibliographic Details
Main Authors: Zhijian Zhu, Manyu Zhang, Dandan Liu, Defei Liu, Tao Sun, Yujing Yang, Jiacheng Dong, Huanhuan Zhai, Wenliang Sun, Qian Liu, Chaoguang Tian
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Microbial Cell Factories
Subjects:
Myceliophthora thermophila
Glucoamylase
Hyper-production
Genetic engineering
Secretion
CRISPR-AsCas12a
Online Access:https://doi.org/10.1186/s12934-023-02149-4

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