Patients with oral cancer do not undergo surgery as primary treatment: A population-based study in Taiwan
Background: There are still oral cancer patients without surgery. To improve the survival, it is necessary to know the causes of the oral cancer patients without surgery. Methods: 23,217 patients with a newly-diagnosed oral cancer in Taiwan Cancer Registry (TCR) database between 2011 and 2015 were e...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | Journal of the Formosan Medical Association |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664619300543 |
| _version_ | 1819162919416365056 |
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| author | Cheng-Ping Wang Li-Jen Liao Chun-Ju Chiang Wan-Lun Hsu Chung-Jan Kang Chen-Chi Wang Peir-Rong Chen Tseng-Cheng Chen Wen-Wei Huang Chih-Yen Chien |
| author_facet | Cheng-Ping Wang Li-Jen Liao Chun-Ju Chiang Wan-Lun Hsu Chung-Jan Kang Chen-Chi Wang Peir-Rong Chen Tseng-Cheng Chen Wen-Wei Huang Chih-Yen Chien |
| author_sort | Cheng-Ping Wang |
| collection | DOAJ |
| description | Background: There are still oral cancer patients without surgery. To improve the survival, it is necessary to know the causes of the oral cancer patients without surgery. Methods: 23,217 patients with a newly-diagnosed oral cancer in Taiwan Cancer Registry (TCR) database between 2011 and 2015 were enrolled. Data from TCR database named “Reason for No Surgery of Primary Site” were extracted for analysis of the causes of those without surgery. Overall survival plots were presented using the Kaplan–Meier method with log-rank test. Results: 3263 (14%) patients did not received surgery. Among them, there were 720 patients (group 3) without surgery although surgery was advised, 154 patients (group 2) because of poor condition or death before surgery, and 2389 patients (group 1) because of other causes. Twenty-four percent of the patients with surgery were treated one month and more after diagnosis. The 5-year overall survival rates were 68.7%, 25.2%, 9.1% and 17.3% for surgery group, group 3, 2 and 1, respectively (p < 0.001). The mean age of the patients with and without surgery were 54.8 and 59.3, respectively (p < 0.01). Female patients were commoner in group 3 (p < 0.01). The patients without surgery was commoner in the middle (15.7%) and southern (14.8%) than in Northern Taiwan (12.1%). All groups without surgery had more advanced stage and lower BMI (p < 0.01). Conclusion: One-sevenths of patients were not treated surgically because of refusal, poor condition, older age, low BMI, and advanced stage. It is necessary to encourage the patients to undergo surgery with shortening the diagnosis-to-treatment interval. Keywords: Oral cancer, Surgery, Refuse treatment, Comorbidity, Head and neck cancer |
| first_indexed | 2024-12-22T17:35:53Z |
| format | Article |
| id | doaj.art-272cb3b70a1d46c3824278085856874a |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-22T17:35:53Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-272cb3b70a1d46c3824278085856874a2022-12-21T18:18:31ZengElsevierJournal of the Formosan Medical Association0929-66462020-01-011191392398Patients with oral cancer do not undergo surgery as primary treatment: A population-based study in TaiwanCheng-Ping Wang0Li-Jen Liao1Chun-Ju Chiang2Wan-Lun Hsu3Chung-Jan Kang4Chen-Chi Wang5Peir-Rong Chen6Tseng-Cheng Chen7Wen-Wei Huang8Chih-Yen Chien9Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, TaiwanDepartment of Otolaryngology, Far Eastern Memorial Hospital, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Taiwan Cancer Registry, Taipei, TaiwanGenomics Research Center, Academia Sinica, Taipei, TaiwanDepartment of Otorhinolaryngology, Head and Neck Surgery, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Otolaryngology, Hualien Tzu Chi Hospital and Tzu Chi University, Hualien, TaiwanDepartment of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, TaiwanDepartment of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Corresponding author. 123, Ta-Pei Road, Niao-Song District, Kaohsiung 833, Taiwan. Fax: +886 7 7313855.Background: There are still oral cancer patients without surgery. To improve the survival, it is necessary to know the causes of the oral cancer patients without surgery. Methods: 23,217 patients with a newly-diagnosed oral cancer in Taiwan Cancer Registry (TCR) database between 2011 and 2015 were enrolled. Data from TCR database named “Reason for No Surgery of Primary Site” were extracted for analysis of the causes of those without surgery. Overall survival plots were presented using the Kaplan–Meier method with log-rank test. Results: 3263 (14%) patients did not received surgery. Among them, there were 720 patients (group 3) without surgery although surgery was advised, 154 patients (group 2) because of poor condition or death before surgery, and 2389 patients (group 1) because of other causes. Twenty-four percent of the patients with surgery were treated one month and more after diagnosis. The 5-year overall survival rates were 68.7%, 25.2%, 9.1% and 17.3% for surgery group, group 3, 2 and 1, respectively (p < 0.001). The mean age of the patients with and without surgery were 54.8 and 59.3, respectively (p < 0.01). Female patients were commoner in group 3 (p < 0.01). The patients without surgery was commoner in the middle (15.7%) and southern (14.8%) than in Northern Taiwan (12.1%). All groups without surgery had more advanced stage and lower BMI (p < 0.01). Conclusion: One-sevenths of patients were not treated surgically because of refusal, poor condition, older age, low BMI, and advanced stage. It is necessary to encourage the patients to undergo surgery with shortening the diagnosis-to-treatment interval. Keywords: Oral cancer, Surgery, Refuse treatment, Comorbidity, Head and neck cancerhttp://www.sciencedirect.com/science/article/pii/S0929664619300543 |
| spellingShingle | Cheng-Ping Wang Li-Jen Liao Chun-Ju Chiang Wan-Lun Hsu Chung-Jan Kang Chen-Chi Wang Peir-Rong Chen Tseng-Cheng Chen Wen-Wei Huang Chih-Yen Chien Patients with oral cancer do not undergo surgery as primary treatment: A population-based study in Taiwan Journal of the Formosan Medical Association |
| title | Patients with oral cancer do not undergo surgery as primary treatment: A population-based study in Taiwan |
| title_full | Patients with oral cancer do not undergo surgery as primary treatment: A population-based study in Taiwan |
| title_fullStr | Patients with oral cancer do not undergo surgery as primary treatment: A population-based study in Taiwan |
| title_full_unstemmed | Patients with oral cancer do not undergo surgery as primary treatment: A population-based study in Taiwan |
| title_short | Patients with oral cancer do not undergo surgery as primary treatment: A population-based study in Taiwan |
| title_sort | patients with oral cancer do not undergo surgery as primary treatment a population based study in taiwan |
| url | http://www.sciencedirect.com/science/article/pii/S0929664619300543 |
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