Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer
The CYP19 gene encodes aromatase, an enzyme catalyzing the conversion of androgens to estrogens. Studies analyzing associations between single nucleotide polymorphisms in CYP19 and breast cancer risk have shown inconsistent results. The rs10046 polymorphism is located in the 3' untranslated reg...
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MDPI AG
2014-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/15/1/712 |
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| author | Karin Zins Maurice Mogg Christian Schneeberger Dietmar Abraham Martin Schreiber |
| author_facet | Karin Zins Maurice Mogg Christian Schneeberger Dietmar Abraham Martin Schreiber |
| author_sort | Karin Zins |
| collection | DOAJ |
| description | The CYP19 gene encodes aromatase, an enzyme catalyzing the conversion of androgens to estrogens. Studies analyzing associations between single nucleotide polymorphisms in CYP19 and breast cancer risk have shown inconsistent results. The rs10046 polymorphism is located in the 3' untranslated region of the CYP19 gene, but the influence of this polymorphism on breast cancer risk is unclear. In this study, we investigated the impact of rs10046 SNP on breast cancer risk, age at onset and association with clinical characteristics in an Austrian population of 274 breast cancer patients and 253 controls. The results show that a significantly increased fraction of patients with the TT genotype of rs10046 develop breast cancer under the age of 50 (41.8% of TT patients, compared to 26.6% of C carriers; p = 0.018, Chi-square test). No rs10046 genotypes were significantly associated with increased breast cancer risk or patient characteristics other than age at onset. These results suggest that the rs10046 polymorphism in the CYP19 gene may have an effect on breast cancer susceptibility at an age under 50 in the investigated population. |
| first_indexed | 2024-04-12T10:15:40Z |
| format | Article |
| id | doaj.art-272cc54f396e46e5913ed2b2f94b0d13 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T10:15:40Z |
| publishDate | 2014-01-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-272cc54f396e46e5913ed2b2f94b0d132022-12-22T03:37:13ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-01-0115171272410.3390/ijms15010712ijms15010712Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast CancerKarin Zins0Maurice Mogg1Christian Schneeberger2Dietmar Abraham3Martin Schreiber4Laboratory for Molecular Cellular Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, A-1090 Vienna, AustriaDepartment of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, AustriaDepartment of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, AustriaLaboratory for Molecular Cellular Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, A-1090 Vienna, AustriaDepartment of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, AustriaThe CYP19 gene encodes aromatase, an enzyme catalyzing the conversion of androgens to estrogens. Studies analyzing associations between single nucleotide polymorphisms in CYP19 and breast cancer risk have shown inconsistent results. The rs10046 polymorphism is located in the 3' untranslated region of the CYP19 gene, but the influence of this polymorphism on breast cancer risk is unclear. In this study, we investigated the impact of rs10046 SNP on breast cancer risk, age at onset and association with clinical characteristics in an Austrian population of 274 breast cancer patients and 253 controls. The results show that a significantly increased fraction of patients with the TT genotype of rs10046 develop breast cancer under the age of 50 (41.8% of TT patients, compared to 26.6% of C carriers; p = 0.018, Chi-square test). No rs10046 genotypes were significantly associated with increased breast cancer risk or patient characteristics other than age at onset. These results suggest that the rs10046 polymorphism in the CYP19 gene may have an effect on breast cancer susceptibility at an age under 50 in the investigated population.http://www.mdpi.com/1422-0067/15/1/712breast cancerCYP19/aromatasers10046rs2236722SNP |
| spellingShingle | Karin Zins Maurice Mogg Christian Schneeberger Dietmar Abraham Martin Schreiber Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer International Journal of Molecular Sciences breast cancer CYP19/aromatase rs10046 rs2236722 SNP |
| title | Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer |
| title_full | Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer |
| title_fullStr | Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer |
| title_full_unstemmed | Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer |
| title_short | Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer |
| title_sort | analysis of the rs10046 polymorphism of aromatase cyp19 in premenopausal onset of human breast cancer |
| topic | breast cancer CYP19/aromatase rs10046 rs2236722 SNP |
| url | http://www.mdpi.com/1422-0067/15/1/712 |
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