Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery
Abstract Nanoparticles are applied as versatile platforms for drug/gene delivery in many applications owing to their long‐retention and specific targeting properties in living bodies. However, the delivery mechanism and the beneficial effect of nanoparticle‐retention in many organisms remain largely...
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202200841 |
| _version_ | 1797817480232566784 |
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| author | Jie Cai Jie Peng Xinwei Zang Juan Feng Ruocheng Li Peng Ren Bingzhu Zheng Jiaying Wang Juan Wang Mi Yan Jianxin Liu Renren Deng Diming Wang |
| author_facet | Jie Cai Jie Peng Xinwei Zang Juan Feng Ruocheng Li Peng Ren Bingzhu Zheng Jiaying Wang Juan Wang Mi Yan Jianxin Liu Renren Deng Diming Wang |
| author_sort | Jie Cai |
| collection | DOAJ |
| description | Abstract Nanoparticles are applied as versatile platforms for drug/gene delivery in many applications owing to their long‐retention and specific targeting properties in living bodies. However, the delivery mechanism and the beneficial effect of nanoparticle‐retention in many organisms remain largely uncertain. Here, the transport and metabolism of mineral nanoparticles in mammary gland during lactation are explored. It is shown that maternal intravenous administration of iron oxide nanoparticles (IONPs; diameter: ≈11.0 nm, surface charge: −29.1 mV, surface area: 1.05 m2 g−1) provides elevated iron delivery to mammary gland and increased iron secretion into breast milk, which is inaccessible by classical iron‐ion transport approaches such as the transferrin receptor‐mediated endocytic pathway. Mammary macrophages and neutrophils are found to play dominant roles in uptake and delivery of IONPs through an unconventional leukocyte‐assisted iron secretion pathway. This pathway bypasses the tight iron concentration regulation of liver hepcidin‐ferroportin axis and mammary epithelial cells to increase milk iron‐ion content derived from IONPs. This work provides keen insight into the metabolic pathway of nanoparticles in mammary gland while offering a new scheme of nutrient delivery for neonate metabolism regulation by using nanosized nutrients. |
| first_indexed | 2024-03-13T08:54:03Z |
| format | Article |
| id | doaj.art-272de3f9557c4db883298bc590319427 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-13T08:54:03Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-272de3f9557c4db883298bc5903194272023-05-29T04:01:39ZengWileyAdvanced Science2198-38442022-09-01926n/an/a10.1002/advs.202200841Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral DeliveryJie Cai0Jie Peng1Xinwei Zang2Juan Feng3Ruocheng Li4Peng Ren5Bingzhu Zheng6Jiaying Wang7Juan Wang8Mi Yan9Jianxin Liu10Renren Deng11Diming Wang12Institute of Dairy Science College of Animal Sciences MOE Key Laboratory of Molecular Animal Nutrition Zhejiang University Hangzhou 310029 P. R. ChinaSchool of Materials Science and Engineering State Key Laboratory of Silicon Materials Institute for Composites Science Innovation Zhejiang University Hangzhou 310027 P. R. ChinaInstitute of Dairy Science College of Animal Sciences MOE Key Laboratory of Molecular Animal Nutrition Zhejiang University Hangzhou 310029 P. R. ChinaInstitute of Dairy Science College of Animal Sciences MOE Key Laboratory of Molecular Animal Nutrition Zhejiang University Hangzhou 310029 P. R. ChinaInstitute of Dairy Science College of Animal Sciences MOE Key Laboratory of Molecular Animal Nutrition Zhejiang University Hangzhou 310029 P. R. ChinaInstitute of Dairy Science College of Animal Sciences MOE Key Laboratory of Molecular Animal Nutrition Zhejiang University Hangzhou 310029 P. R. ChinaSchool of Materials Science and Engineering State Key Laboratory of Silicon Materials Institute for Composites Science Innovation Zhejiang University Hangzhou 310027 P. R. ChinaInstitute of Environmental Health MOE Key Laboratory of Environmental Remediation and Ecosystem Health College of Environmental & Resource Sciences Zhejiang University Hangzhou 310058 P. R. ChinaInstitute of Environmental Health MOE Key Laboratory of Environmental Remediation and Ecosystem Health College of Environmental & Resource Sciences Zhejiang University Hangzhou 310058 P. R. ChinaSchool of Materials Science and Engineering State Key Laboratory of Silicon Materials Institute for Composites Science Innovation Zhejiang University Hangzhou 310027 P. R. ChinaInstitute of Dairy Science College of Animal Sciences MOE Key Laboratory of Molecular Animal Nutrition Zhejiang University Hangzhou 310029 P. R. ChinaSchool of Materials Science and Engineering State Key Laboratory of Silicon Materials Institute for Composites Science Innovation Zhejiang University Hangzhou 310027 P. R. ChinaInstitute of Dairy Science College of Animal Sciences MOE Key Laboratory of Molecular Animal Nutrition Zhejiang University Hangzhou 310029 P. R. ChinaAbstract Nanoparticles are applied as versatile platforms for drug/gene delivery in many applications owing to their long‐retention and specific targeting properties in living bodies. However, the delivery mechanism and the beneficial effect of nanoparticle‐retention in many organisms remain largely uncertain. Here, the transport and metabolism of mineral nanoparticles in mammary gland during lactation are explored. It is shown that maternal intravenous administration of iron oxide nanoparticles (IONPs; diameter: ≈11.0 nm, surface charge: −29.1 mV, surface area: 1.05 m2 g−1) provides elevated iron delivery to mammary gland and increased iron secretion into breast milk, which is inaccessible by classical iron‐ion transport approaches such as the transferrin receptor‐mediated endocytic pathway. Mammary macrophages and neutrophils are found to play dominant roles in uptake and delivery of IONPs through an unconventional leukocyte‐assisted iron secretion pathway. This pathway bypasses the tight iron concentration regulation of liver hepcidin‐ferroportin axis and mammary epithelial cells to increase milk iron‐ion content derived from IONPs. This work provides keen insight into the metabolic pathway of nanoparticles in mammary gland while offering a new scheme of nutrient delivery for neonate metabolism regulation by using nanosized nutrients.https://doi.org/10.1002/advs.202200841leukocytemammary glandmilkmineral nanoparticlesnutrient delivery |
| spellingShingle | Jie Cai Jie Peng Xinwei Zang Juan Feng Ruocheng Li Peng Ren Bingzhu Zheng Jiaying Wang Juan Wang Mi Yan Jianxin Liu Renren Deng Diming Wang Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery Advanced Science leukocyte mammary gland milk mineral nanoparticles nutrient delivery |
| title | Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery |
| title_full | Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery |
| title_fullStr | Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery |
| title_full_unstemmed | Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery |
| title_short | Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery |
| title_sort | mammary leukocyte assisted nanoparticle transport enhances targeted milk trace mineral delivery |
| topic | leukocyte mammary gland milk mineral nanoparticles nutrient delivery |
| url | https://doi.org/10.1002/advs.202200841 |
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