Vitamin D intake and gastric cancer in Viet Nam: a case-control study
Abstract Background Most recent laboratory studies have suggested a promising role of vitamin D and its analogs as novel chemotherapeutic agents for cancer treatment. However, epidemiological evidence, especially regarding the effects of vitamin D on gastric cancer is still inconsistent. Objectives...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-022-09933-2 |
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| author | Minh Thien Nguyen Nhi Ngoc Yen Huynh Dai Duc Nguyen Nguyen Ha Ta Tai Van Nguyen Huy Thanh Dang Ngoan Tran Le |
| author_facet | Minh Thien Nguyen Nhi Ngoc Yen Huynh Dai Duc Nguyen Nguyen Ha Ta Tai Van Nguyen Huy Thanh Dang Ngoan Tran Le |
| author_sort | Minh Thien Nguyen |
| collection | DOAJ |
| description | Abstract Background Most recent laboratory studies have suggested a promising role of vitamin D and its analogs as novel chemotherapeutic agents for cancer treatment. However, epidemiological evidence, especially regarding the effects of vitamin D on gastric cancer is still inconsistent. Objectives Our research aimed to evaluate the associations between vitamin D intake and the risk of developing gastric cancer through a case-control study in North Vietnam. Methods We accessed databases of the previous completed case-control studies to derive 1182 incident gastric cancer cases and 2995 hospital controls selected from hospitals in Hanoi from 2003 to 2019. Vitamin D intake was computed by multiplying the food frequency intake with nutrient content based on the Viet Nam Food Composition Tables. Data were collected through face-to-face interviews by trained interviewers using the validated semi-quantitative food frequency and demographic lifestyle questionnaires. The odds ratio and 95% confidence interval (OR and 95%CI) were estimated using unconditional logistic regression analysis. Results We observed a continual decline in gastric cancer risk according to the level-up of vitamin D intake in both genders, men, and women [Fifth vs. bottom quintile, OR, 95%CI: 0.68 (0.53, 0.86), OR, 95%CI: 0.72 (0.53, 0.97), OR, 95%CI: 0.58 (0.38, 0.89), respectively. Per increment quintile, the statistically significant decreased risk was seen by 7% in men and 13% in women. The significant inverse association between vitamin D intake remained in the subgroups of ever and never tobacco smoking; negative and positive H. pylori infection. Conclusion The findings suggested that sufficient vitamin D intake was associated with a lower risk of Gastric Cancer in the Vietnamese population. |
| first_indexed | 2024-04-13T11:29:23Z |
| format | Article |
| id | doaj.art-272eb4e77da04267a5b8fdd522902e81 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T11:29:23Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-272eb4e77da04267a5b8fdd522902e812022-12-22T02:48:36ZengBMCBMC Cancer1471-24072022-08-012211910.1186/s12885-022-09933-2Vitamin D intake and gastric cancer in Viet Nam: a case-control studyMinh Thien Nguyen0Nhi Ngoc Yen Huynh1Dai Duc Nguyen2Nguyen Ha Ta3Tai Van Nguyen4Huy Thanh Dang5Ngoan Tran Le6School of Medicine, International University of Health and WelfareSchool of Medicine, International University of Health and WelfareSchool of Medicine, International University of Health and WelfareSchool of Medicine, International University of Health and WelfareSchool of Medicine, International University of Health and WelfareSchool of Medicine, International University of Health and WelfareInstitute of Research and Development, Duy Tan UniversityAbstract Background Most recent laboratory studies have suggested a promising role of vitamin D and its analogs as novel chemotherapeutic agents for cancer treatment. However, epidemiological evidence, especially regarding the effects of vitamin D on gastric cancer is still inconsistent. Objectives Our research aimed to evaluate the associations between vitamin D intake and the risk of developing gastric cancer through a case-control study in North Vietnam. Methods We accessed databases of the previous completed case-control studies to derive 1182 incident gastric cancer cases and 2995 hospital controls selected from hospitals in Hanoi from 2003 to 2019. Vitamin D intake was computed by multiplying the food frequency intake with nutrient content based on the Viet Nam Food Composition Tables. Data were collected through face-to-face interviews by trained interviewers using the validated semi-quantitative food frequency and demographic lifestyle questionnaires. The odds ratio and 95% confidence interval (OR and 95%CI) were estimated using unconditional logistic regression analysis. Results We observed a continual decline in gastric cancer risk according to the level-up of vitamin D intake in both genders, men, and women [Fifth vs. bottom quintile, OR, 95%CI: 0.68 (0.53, 0.86), OR, 95%CI: 0.72 (0.53, 0.97), OR, 95%CI: 0.58 (0.38, 0.89), respectively. Per increment quintile, the statistically significant decreased risk was seen by 7% in men and 13% in women. The significant inverse association between vitamin D intake remained in the subgroups of ever and never tobacco smoking; negative and positive H. pylori infection. Conclusion The findings suggested that sufficient vitamin D intake was associated with a lower risk of Gastric Cancer in the Vietnamese population.https://doi.org/10.1186/s12885-022-09933-2Vitamin DGastric cancerEpidemiologyCase-control studyViet Nam |
| spellingShingle | Minh Thien Nguyen Nhi Ngoc Yen Huynh Dai Duc Nguyen Nguyen Ha Ta Tai Van Nguyen Huy Thanh Dang Ngoan Tran Le Vitamin D intake and gastric cancer in Viet Nam: a case-control study BMC Cancer Vitamin D Gastric cancer Epidemiology Case-control study Viet Nam |
| title | Vitamin D intake and gastric cancer in Viet Nam: a case-control study |
| title_full | Vitamin D intake and gastric cancer in Viet Nam: a case-control study |
| title_fullStr | Vitamin D intake and gastric cancer in Viet Nam: a case-control study |
| title_full_unstemmed | Vitamin D intake and gastric cancer in Viet Nam: a case-control study |
| title_short | Vitamin D intake and gastric cancer in Viet Nam: a case-control study |
| title_sort | vitamin d intake and gastric cancer in viet nam a case control study |
| topic | Vitamin D Gastric cancer Epidemiology Case-control study Viet Nam |
| url | https://doi.org/10.1186/s12885-022-09933-2 |
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