Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole

Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole

Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug candidates are often discontinued in the primary stag...

Full description

Bibliographic Details
Main Authors:	Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	Pharmaceuticals
Subjects:	aminooxazole aminothiazole antimycobacterial activity docking molecular docking molecular dynamics
Online Access:	https://www.mdpi.com/1424-8247/15/5/580

Similar Items

Correction: Juhás et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. <i>Pharmaceuticals</i> 2022, <i>15</i>, 580
by: Martin Juhás, et al.
Published: (2023-03-01)

Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity
by: Vinod Sukanth Kumar Pallabothula, et al.
Published: (2022-10-01)

Multifunctional Isosteric Pyridine Analogs-Based 2-Aminothiazole: Design, Synthesis, and Potential Phosphodiesterase-5 Inhibitory Activity
by: Abdel Haleem M. Hussein, et al.
Published: (2021-02-01)

Design, Synthesis and Antimicrobial Evaluation of New <i>N</i>-(1-Hydroxy-1,3-dihydrobenzo[<i>c</i>][1,2]oxaborol-6-yl)(hetero)aryl-2-carboxamides as Potential Inhibitors of Mycobacterial Leucyl-tRNA Synthetase
by: Petr Šlechta, et al.
Published: (2023-02-01)

Synthesis, Biological Evaluation, and In Silico Modeling of <i>N</i>-Substituted Quinoxaline-2-Carboxamides
by: Ghada Bouz, et al.
Published: (2021-08-01)

Designing, synthesis and characterization of 2-aminothiazole-4-carboxylate Schiff bases; antimicrobial evaluation against multidrug resistant strains and molecular docking
by: Saima Ejaz, et al.
Published: (2019-09-01)

Design, Synthesis, In-silico ADME prediction Molecular docking and Antitubercular screening of Bromo-pyridyl tethered 3-chloro 2-azetidinone Derivatives
by: Rakesh V. Kusurkar, et al.
Published: (2022-01-01)

5-Alkylamino-<i>N</i>-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation
by: Weronika Ambrożkiewicz, et al.
Published: (2020-03-01)

<i>N</i>-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers
by: Martin Juhás, et al.
Published: (2020-03-01)

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities
by: Mohamed Farouk Elsadek, et al.
Published: (2021-03-01)

In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA)
by: Umaa Kuppuswamy, et al.
Published: (2022-12-01)

Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative
by: Alexandru Maria-Gabriela, et al.
Published: (2010-06-01)

Synthesis and Evaluation of Aminothiazole-Paeonol Derivatives as Potential Anticancer Agents
by: Chia-Ying Tsai, et al.
Published: (2016-01-01)

Computer-aided drug design of capuramycin analogues as anti-tuberculosis antibiotics by 3D-QSAR and molecular docking
by: Jin Yuanyuan, et al.
Published: (2017-12-01)

Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents
by: Jan Zitko, et al.
Published: (2018-09-01)

Recent Developments and Biological Activities of 2-Aminothiazole Derivatives
by: Mohamed Ezzat Khalifa
Published: (2018-03-01)

Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation
by: Naz S, et al.
Published: (2021-04-01)

Novel Hybrid Compounds Containing Benzofuroxan and Aminothiazole Scaffolds: Synthesis and Evaluation of Their Anticancer Activity
by: Elena Chugunova, et al.
Published: (2021-07-01)

Antimycobacterial Drugs as a Novel Strategy to Inhibit <i>Pseudomonas aeruginosa</i> Virulence Factors and Combat Antibiotic Resistance: A Molecular Simulation Study
by: Razique Anwer
Published: (2024-02-01)

Preparation and Biological Activities of Some Heterocyclic Compounds Derivatives from 2-Aminothiazoles
by: Faez Abdul-hussein Alrammahi
Published: (2018-06-01)

Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity
by: Ghada Bouz, et al.
Published: (2019-03-01)

A one-pot electrochemical synthesis of 2-aminothiazoles from active methylene ketones and thioureas mediated by NH4I
by: Shang-Feng Yang, et al.
Published: (2022-09-01)

Enhanced photocatalytic reduction of Hg(II) in aqueous medium by 2-aminothiazole-modified TiO2 particles
by: Cristante Valtair M., et al.
Published: (2006-01-01)

Synthesis of Poly(2-aminothiazole)-Coated Polystyrene Particles and Their Excellent Hg(II) Adsorption Properties
by: Hua Zou, et al.
Published: (2020-03-01)

2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma
by: Rayane Hedna, et al.
Published: (2023-10-01)

Molecular Docking Study of Four Chromene Derivatives as Novel HIV-1 Integrase Inhibitors
by: Nevin Arslan
Published: (2019-06-01)

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Studies of 3-(Phenylcarbamoyl)-pyrazine-2-carboxylic Acids
by: Lucia Semelková, et al.
Published: (2017-09-01)

Modeling EphB4-EphrinB2 protein–protein interaction using flexible docking of a short linear motif
by: Maciej Pawel Ciemny, et al.
Published: (2017-08-01)

Cobdock: an accurate and practical machine learning-based consensus blind docking method
by: Sadettin Y. Ugurlu, et al.
Published: (2024-01-01)

Development of New Antimycobacterial Sulfonyl Hydrazones and 4-Methyl-1,2,3-thiadiazole-Based Hydrazone Derivatives
by: Violina T. Angelova, et al.
Published: (2022-04-01)

Determination of Cu, Ni and Pb in aqueous medium by FAAS after pre-concentration on 2-aminothiazole modified silica gel
by: Alcântara Ilton Luiz de, et al.
Published: (2004-01-01)

Cover, Content, and Editorial Note from J Mol Docking Vol. 2 No. 1 June 2022
by: Chief Editor of J Mol Docking
Published: (2022-06-01)

Cover, Content, and Editorial Note from J Mol Docking Vol. 1 No. 1 June 2021
by: Chief Editor of J Mol Docking
Published: (2021-06-01)

Consensus combining outcomes of multiple ensemble dockings: examples using dDAT crystalized complexes
by: Fabiani Triches, et al.
Published: (2022-01-01)

SPIONs as a nanomagnetic catalyst for the synthesis and anti-microbial activity of 2-aminothiazoles derivatives
by: Samar A. Abubshait, et al.
Published: (2022-07-01)

New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies
by: Elena Pini, et al.
Published: (2018-06-01)

Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides
by: Jan Zitko, et al.
Published: (2013-12-01)

Synthesizing, Studying Molecular Docking, Characterizing, and Preliminary Evaluating Anti-Bacterial Effects of Derivatives of Serotonin Contain Imidazolidine Ring
by: Marwa Abdullah Saleh, et al.
Published: (2022-10-01)

Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1β and NF-κB Proteins
by: Gabriel Zazeri, et al.
Published: (2020-06-01)

Integrating Pharmacological and Computational Approaches for the Phytochemical Analysis of <em>Syzygium cumini</em> and Its Anti-Diabetic Potential
by: Fatima Rashid, et al.
Published: (2022-09-01)