Activin A more prominently regulates muscle mass in primates than does GDF8
Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15153 |
| _version_ | 1818400453901156352 |
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| author | Esther Latres Jason Mastaitis Wen Fury Lawrence Miloscio Jesus Trejos Jeffrey Pangilinan Haruka Okamoto Katie Cavino Erqian Na Angelos Papatheodorou Tobias Willer Yu Bai Jee Hae Kim Ashique Rafique Stephen Jaspers Trevor Stitt Andrew J. Murphy George D. Yancopoulos Jesper Gromada |
| author_facet | Esther Latres Jason Mastaitis Wen Fury Lawrence Miloscio Jesus Trejos Jeffrey Pangilinan Haruka Okamoto Katie Cavino Erqian Na Angelos Papatheodorou Tobias Willer Yu Bai Jee Hae Kim Ashique Rafique Stephen Jaspers Trevor Stitt Andrew J. Murphy George D. Yancopoulos Jesper Gromada |
| author_sort | Esther Latres |
| collection | DOAJ |
| description | Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates. |
| first_indexed | 2024-12-14T07:36:49Z |
| format | Article |
| id | doaj.art-27340da65b5f447ab24e6f3d810b70d9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:36:49Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-27340da65b5f447ab24e6f3d810b70d92022-12-21T23:11:09ZengNature PortfolioNature Communications2041-17232017-04-018111310.1038/ncomms15153Activin A more prominently regulates muscle mass in primates than does GDF8Esther Latres0Jason Mastaitis1Wen Fury2Lawrence Miloscio3Jesus Trejos4Jeffrey Pangilinan5Haruka Okamoto6Katie Cavino7Erqian Na8Angelos Papatheodorou9Tobias Willer10Yu Bai11Jee Hae Kim12Ashique Rafique13Stephen Jaspers14Trevor Stitt15Andrew J. Murphy16George D. Yancopoulos17Jesper Gromada18Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.https://doi.org/10.1038/ncomms15153 |
| spellingShingle | Esther Latres Jason Mastaitis Wen Fury Lawrence Miloscio Jesus Trejos Jeffrey Pangilinan Haruka Okamoto Katie Cavino Erqian Na Angelos Papatheodorou Tobias Willer Yu Bai Jee Hae Kim Ashique Rafique Stephen Jaspers Trevor Stitt Andrew J. Murphy George D. Yancopoulos Jesper Gromada Activin A more prominently regulates muscle mass in primates than does GDF8 Nature Communications |
| title | Activin A more prominently regulates muscle mass in primates than does GDF8 |
| title_full | Activin A more prominently regulates muscle mass in primates than does GDF8 |
| title_fullStr | Activin A more prominently regulates muscle mass in primates than does GDF8 |
| title_full_unstemmed | Activin A more prominently regulates muscle mass in primates than does GDF8 |
| title_short | Activin A more prominently regulates muscle mass in primates than does GDF8 |
| title_sort | activin a more prominently regulates muscle mass in primates than does gdf8 |
| url | https://doi.org/10.1038/ncomms15153 |
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