Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells

Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells

Background/Aims: The goal of this study was to detect the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human retinal pigmented epithelial (RPE) cells treated with celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, under hypoxic and normo...

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Bibliographic Details
Main Authors:	Yi-zhou Sun, Na Cai, Ning-ning Liu
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2017-12-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Cyclooxygenase-2 inhibitor Hypoxia-inducible factor 1α Vascular endothelial growth factor PI3K/AKT pathway Human retinal pigmented epithelial cells
Online Access:	https://www.karger.com/Article/FullText/485764

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