Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring
Summary: It is imperative to explore biomarkers that are both precise and readily accessible in the comprehensive management of breast cancer. A multicenter cohort, including 512 breast cancer patients and 198 nonneoplastic individuals, was recruited to detect the level of tumor-derived extracellula...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224007272 |
| _version_ | 1797237950757470208 |
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| author | Feng Xu Ke Wang Chengjun Zhu Lingling Fan Ye Zhu Jacqueline F. Wang Xintong Li Yiqiu Liu Yuhan Zhao Chuandong Zhu Wenwen Zhang Fang Yang Jian Xu Zhe Li Xiaoxiang Guan |
| author_facet | Feng Xu Ke Wang Chengjun Zhu Lingling Fan Ye Zhu Jacqueline F. Wang Xintong Li Yiqiu Liu Yuhan Zhao Chuandong Zhu Wenwen Zhang Fang Yang Jian Xu Zhe Li Xiaoxiang Guan |
| author_sort | Feng Xu |
| collection | DOAJ |
| description | Summary: It is imperative to explore biomarkers that are both precise and readily accessible in the comprehensive management of breast cancer. A multicenter cohort, including 512 breast cancer patients and 198 nonneoplastic individuals, was recruited to detect the level of tumor-derived extracellular vesicles using our method based on dual DNA tetrahedral nanostructures. The level of tumor-derived extracellular vesicles was significantly higher in newly diagnosed breast cancer patients than in nonneoplastic individuals at a cutoff value of 3.58 U/μL. For postoperative metastasis monitoring, the level of tumor-derived extracellular vesicles was significantly higher in breast cancer patients with metastasis than in those without metastasis at a cutoff value of 3.91 U/μL. Its efficacy of diagnosis and metastasis monitoring was superior to traditional tumor markers. Elevated level of tumor-derived extracellular vesicles served as a predictive biomarker for diagnosis and metastasis monitoring in breast cancer patients. |
| first_indexed | 2024-04-24T17:27:54Z |
| format | Article |
| id | doaj.art-27376b7c048c4b1094b268728330fc22 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-24T17:27:54Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-27376b7c048c4b1094b268728330fc222024-03-28T06:38:36ZengElsevieriScience2589-00422024-04-01274109506Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoringFeng Xu0Ke Wang1Chengjun Zhu2Lingling Fan3Ye Zhu4Jacqueline F. Wang5Xintong Li6Yiqiu Liu7Yuhan Zhao8Chuandong Zhu9Wenwen Zhang10Fang Yang11Jian Xu12Zhe Li13Xiaoxiang Guan14Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Medicine, NYU Langone Health, 550 First Avenue, New York 10016, NY, USADepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, Nanjing Second Hospital, Nanjing, ChinaDepartment of Oncology, Nanjing First Hospital, Nanjing, ChinaThe Comprehensive Cancer Center of Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing , ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Corresponding authorDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, China; State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China; Corresponding authorDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, China; Corresponding authorSummary: It is imperative to explore biomarkers that are both precise and readily accessible in the comprehensive management of breast cancer. A multicenter cohort, including 512 breast cancer patients and 198 nonneoplastic individuals, was recruited to detect the level of tumor-derived extracellular vesicles using our method based on dual DNA tetrahedral nanostructures. The level of tumor-derived extracellular vesicles was significantly higher in newly diagnosed breast cancer patients than in nonneoplastic individuals at a cutoff value of 3.58 U/μL. For postoperative metastasis monitoring, the level of tumor-derived extracellular vesicles was significantly higher in breast cancer patients with metastasis than in those without metastasis at a cutoff value of 3.91 U/μL. Its efficacy of diagnosis and metastasis monitoring was superior to traditional tumor markers. Elevated level of tumor-derived extracellular vesicles served as a predictive biomarker for diagnosis and metastasis monitoring in breast cancer patients.http://www.sciencedirect.com/science/article/pii/S2589004224007272OncologyFunctional aspects of cell biology |
| spellingShingle | Feng Xu Ke Wang Chengjun Zhu Lingling Fan Ye Zhu Jacqueline F. Wang Xintong Li Yiqiu Liu Yuhan Zhao Chuandong Zhu Wenwen Zhang Fang Yang Jian Xu Zhe Li Xiaoxiang Guan Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring iScience Oncology Functional aspects of cell biology |
| title | Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring |
| title_full | Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring |
| title_fullStr | Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring |
| title_full_unstemmed | Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring |
| title_short | Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring |
| title_sort | tumor derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring |
| topic | Oncology Functional aspects of cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224007272 |
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