Goldmann Tonometry and Corneal Biomechanics
Glaucoma is the second cause of irreversible blindness in the world. Intraocular pressure (IOP) is a recognized major risk factor for the development and progression of glaucomatous damage. Goldmann applanation tonometry (GAT) is internationally accepted as the gold standard for the measurement of I...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/9/4025 |
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| author | Dario Messenio Marco Ferroni Federica Boschetti |
| author_facet | Dario Messenio Marco Ferroni Federica Boschetti |
| author_sort | Dario Messenio |
| collection | DOAJ |
| description | Glaucoma is the second cause of irreversible blindness in the world. Intraocular pressure (IOP) is a recognized major risk factor for the development and progression of glaucomatous damage. Goldmann applanation tonometry (GAT) is internationally accepted as the gold standard for the measurement of IOP. The purpose of this study was to search for correlations between Goldmann tonometry and corneal mechanical properties and thickness by means of in vitro tests. IOP was measured by the Goldmann applanation tonometer (GIOP), and by a pressure transducer inserted in the anterior chamber of the eye (TIOP), at increasing pressure levels by addition of saline solution in the anterior chamber of enucleated pig eyes (n = 49). Mechanical properties were also determined by inflation tests. The GAT underestimated the real measurements made by the pressure transducer, with most common differences in the range 15–28 mmHg. The difference between the two instruments, highlighted by the Bland–Altman test, was confirmed by ANOVA, normality tests, and Mann–Whitney’s tests, both on the data arranged for infusions and for the data organized by pressure ranges. Pearson correlation tests revealed a negative correlation between (TIOP-GIOP) and both corneal stiffness and corneal thickness. In conclusion, data obtained showed a discrepancy between GIOP and TIOP more evident for softer and thinner corneas, that is very important for glaucoma detection. |
| first_indexed | 2024-03-10T11:51:50Z |
| format | Article |
| id | doaj.art-2738a162c7ab4d8faa87f0abaac8f4f6 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T11:51:50Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-2738a162c7ab4d8faa87f0abaac8f4f62023-11-21T17:38:45ZengMDPI AGApplied Sciences2076-34172021-04-01119402510.3390/app11094025Goldmann Tonometry and Corneal BiomechanicsDario Messenio0Marco Ferroni1Federica Boschetti2ASST Fatebenefratelli Sacco, Department of Clinical Sciences, Eye Clinic, University of Milan, 20157 Milan, ItalyDepartment of Chemistry, Materials and Chemical Engineering, “Giulio Natta”, Politecnico di Milano, 20133 Milan, ItalyDepartment of Chemistry, Materials and Chemical Engineering, “Giulio Natta”, Politecnico di Milano, 20133 Milan, ItalyGlaucoma is the second cause of irreversible blindness in the world. Intraocular pressure (IOP) is a recognized major risk factor for the development and progression of glaucomatous damage. Goldmann applanation tonometry (GAT) is internationally accepted as the gold standard for the measurement of IOP. The purpose of this study was to search for correlations between Goldmann tonometry and corneal mechanical properties and thickness by means of in vitro tests. IOP was measured by the Goldmann applanation tonometer (GIOP), and by a pressure transducer inserted in the anterior chamber of the eye (TIOP), at increasing pressure levels by addition of saline solution in the anterior chamber of enucleated pig eyes (n = 49). Mechanical properties were also determined by inflation tests. The GAT underestimated the real measurements made by the pressure transducer, with most common differences in the range 15–28 mmHg. The difference between the two instruments, highlighted by the Bland–Altman test, was confirmed by ANOVA, normality tests, and Mann–Whitney’s tests, both on the data arranged for infusions and for the data organized by pressure ranges. Pearson correlation tests revealed a negative correlation between (TIOP-GIOP) and both corneal stiffness and corneal thickness. In conclusion, data obtained showed a discrepancy between GIOP and TIOP more evident for softer and thinner corneas, that is very important for glaucoma detection.https://www.mdpi.com/2076-3417/11/9/4025Goldmann tonometryintraocular pressureglaucomainflation testspig eyescorneal stiffness |
| spellingShingle | Dario Messenio Marco Ferroni Federica Boschetti Goldmann Tonometry and Corneal Biomechanics Applied Sciences Goldmann tonometry intraocular pressure glaucoma inflation tests pig eyes corneal stiffness |
| title | Goldmann Tonometry and Corneal Biomechanics |
| title_full | Goldmann Tonometry and Corneal Biomechanics |
| title_fullStr | Goldmann Tonometry and Corneal Biomechanics |
| title_full_unstemmed | Goldmann Tonometry and Corneal Biomechanics |
| title_short | Goldmann Tonometry and Corneal Biomechanics |
| title_sort | goldmann tonometry and corneal biomechanics |
| topic | Goldmann tonometry intraocular pressure glaucoma inflation tests pig eyes corneal stiffness |
| url | https://www.mdpi.com/2076-3417/11/9/4025 |
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