Mechanism and application of ferroptosis in colorectal cancer
Colorectal cancer (CRC) is the third most common malignant tumor in the world. CRC has high morbidity and mortality rates and it is a serious threat to human health. Ferroptosis is a unique form of iron-dependent oxidative cell death that is usually accompanied by iron accumulation and lipid peroxid...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222014913 |
| _version_ | 1811177264256122880 |
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| author | Liu Yang Yewei Zhang Yingyi Zhang Zhe Fan |
| author_facet | Liu Yang Yewei Zhang Yingyi Zhang Zhe Fan |
| author_sort | Liu Yang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most common malignant tumor in the world. CRC has high morbidity and mortality rates and it is a serious threat to human health. Ferroptosis is a unique form of iron-dependent oxidative cell death that is usually accompanied by iron accumulation and lipid peroxidation. Ferroptosis has attracted worldwide attention since it was first proposed. It plays an important role in the development of a variety of diseases, such as tumors, ischemia/reperfusion injury, nervous system diseases, and kidney damage, and it may serve as a new therapeutic target. This article reviews the mechanism of ferroptosis and the possibility to target ferroptosis pathways in CRC, providing new ideas for the diagnosis and treatment of CRC. |
| first_indexed | 2024-04-10T22:58:47Z |
| format | Article |
| id | doaj.art-2738a6930fb74b188cc9282f5694bc25 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T22:58:47Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-2738a6930fb74b188cc9282f5694bc252023-01-14T04:25:46ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-02-01158114102Mechanism and application of ferroptosis in colorectal cancerLiu Yang0Yewei Zhang1Yingyi Zhang2Zhe Fan3Department of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical University, Dalian, China; Department of Central Laboratory, The Third People’s Hospital of Dalian, Dalian Medical University, Dalian, China; Liaoning Province Key Laboratory of Corneal and Ocular Surface Diseases Research, The Third People’s Hospital of Dalian, Dalian, ChinaDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China; Corresponding author.Department of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical University, Dalian, China; Department of Central Laboratory, The Third People’s Hospital of Dalian, Dalian Medical University, Dalian, China; Liaoning Province Key Laboratory of Corneal and Ocular Surface Diseases Research, The Third People’s Hospital of Dalian, Dalian, China; Corresponding authors at: Department of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical University, Dalian, China.Department of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical University, Dalian, China; Department of Central Laboratory, The Third People’s Hospital of Dalian, Dalian Medical University, Dalian, China; Liaoning Province Key Laboratory of Corneal and Ocular Surface Diseases Research, The Third People’s Hospital of Dalian, Dalian, China; Corresponding authors at: Department of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical University, Dalian, China.Colorectal cancer (CRC) is the third most common malignant tumor in the world. CRC has high morbidity and mortality rates and it is a serious threat to human health. Ferroptosis is a unique form of iron-dependent oxidative cell death that is usually accompanied by iron accumulation and lipid peroxidation. Ferroptosis has attracted worldwide attention since it was first proposed. It plays an important role in the development of a variety of diseases, such as tumors, ischemia/reperfusion injury, nervous system diseases, and kidney damage, and it may serve as a new therapeutic target. This article reviews the mechanism of ferroptosis and the possibility to target ferroptosis pathways in CRC, providing new ideas for the diagnosis and treatment of CRC.http://www.sciencedirect.com/science/article/pii/S0753332222014913FerroptosisCRCSignaling pathwayGSHROS |
| spellingShingle | Liu Yang Yewei Zhang Yingyi Zhang Zhe Fan Mechanism and application of ferroptosis in colorectal cancer Biomedicine & Pharmacotherapy Ferroptosis CRC Signaling pathway GSH ROS |
| title | Mechanism and application of ferroptosis in colorectal cancer |
| title_full | Mechanism and application of ferroptosis in colorectal cancer |
| title_fullStr | Mechanism and application of ferroptosis in colorectal cancer |
| title_full_unstemmed | Mechanism and application of ferroptosis in colorectal cancer |
| title_short | Mechanism and application of ferroptosis in colorectal cancer |
| title_sort | mechanism and application of ferroptosis in colorectal cancer |
| topic | Ferroptosis CRC Signaling pathway GSH ROS |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222014913 |
| work_keys_str_mv | AT liuyang mechanismandapplicationofferroptosisincolorectalcancer AT yeweizhang mechanismandapplicationofferroptosisincolorectalcancer AT yingyizhang mechanismandapplicationofferroptosisincolorectalcancer AT zhefan mechanismandapplicationofferroptosisincolorectalcancer |