Toward a Systematic Assessment of Sex Differences in Cystic Fibrosis
(1) Background: Cystic fibrosis (CF) is a disease with well-documented clinical differences between female and male patients. However, this <i>gender gap</i> is very poorly studied at the molecular level. (2) Methods: Expression differences in whole blood transcriptomics between female a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/13/6/924 |
| Summary: | (1) Background: Cystic fibrosis (CF) is a disease with well-documented clinical differences between female and male patients. However, this <i>gender gap</i> is very poorly studied at the molecular level. (2) Methods: Expression differences in whole blood transcriptomics between female and male CF patients are analyzed in order to determine the pathways related to sex-biased genes and assess their potential influence on sex-specific effects in CF patients. (3) Results: We identify sex-biased genes in female and male CF patients and provide explanations for some sex-specific differences at the molecular level. (4) Conclusion: Genes in key pathways associated with CF are differentially expressed between sexes, and thus may account for the gender gap in morbidity and mortality in CF. |
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| ISSN: | 2075-4426 |