Molecular Phenotyping of AR Signaling for Predicting Targeted Therapy in Castration Resistant Prostate Cancer

Molecular Phenotyping of AR Signaling for Predicting Targeted Therapy in Castration Resistant Prostate Cancer

Castration-resistant prostate cancer (CRPC) is defined by resistance of the tumor to androgen deprivation therapy (ADT). Several molecular changes, particularly in the AR signaling cascade, have been described that may explain ADT resistance. The variety of changes may also explain why the response...

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Bibliographic Details
Main Authors: Agus Rizal A. H. Hamid, Maria V. Luna-Velez, Aleksandra M. Dudek, Cornelius F. J. Jansen, Frank Smit, Tilly W. Aalders, Gerald W. Verhaegh, Ewout Schaafsma, John P. M. Sedelaar, Jack A. Schalken
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
castration-resistant prostate cancer
androgen receptor
gene amplification
splice variant
gene mutation
steroidogenic enzymes
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.721659/full

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