Alternate Antimicrobial Therapies and Their Companion Tests
New antimicrobial approaches are essential to counter antimicrobial resistance. The drug development pipeline is exhausted with the emergence of resistance, resulting in unsuccessful trials. The lack of an effective drug developed from the conventional drug portfolio has mandated the introspection i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/15/2490 |
| _version_ | 1797586859618992128 |
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| author | Sriram Kalpana Wan-Ying Lin Yu-Chiang Wang Yiwen Fu Hsin-Yao Wang |
| author_facet | Sriram Kalpana Wan-Ying Lin Yu-Chiang Wang Yiwen Fu Hsin-Yao Wang |
| author_sort | Sriram Kalpana |
| collection | DOAJ |
| description | New antimicrobial approaches are essential to counter antimicrobial resistance. The drug development pipeline is exhausted with the emergence of resistance, resulting in unsuccessful trials. The lack of an effective drug developed from the conventional drug portfolio has mandated the introspection into the list of potentially effective unconventional alternate antimicrobial molecules. Alternate therapies with clinically explicable forms include monoclonal antibodies, antimicrobial peptides, aptamers, and phages. Clinical diagnostics optimize the drug delivery. In the era of diagnostic-based applications, it is logical to draw diagnostic-based treatment for infectious diseases. Selection criteria of alternate therapeutics in infectious diseases include detection, monitoring of response, and resistance mechanism identification. Integrating these diagnostic applications is disruptive to the traditional therapeutic development. The challenges and mitigation methods need to be noted. Applying the goals of clinical pharmacokinetics that include enhancing efficacy and decreasing toxicity of drug therapy, this review analyses the strong correlation of alternate antimicrobial therapeutics in infectious diseases. The relationship between drug concentration and the resulting effect defined by the pharmacodynamic parameters are also analyzed. This review analyzes the perspectives of aligning diagnostic initiatives with the use of alternate therapeutics, with a particular focus on companion diagnostic applications in infectious diseases. |
| first_indexed | 2024-03-11T00:29:08Z |
| format | Article |
| id | doaj.art-273ef8d7ba8d4cc2ae4736dd6df7d6ca |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T00:29:08Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-273ef8d7ba8d4cc2ae4736dd6df7d6ca2023-11-18T22:46:13ZengMDPI AGDiagnostics2075-44182023-07-011315249010.3390/diagnostics13152490Alternate Antimicrobial Therapies and Their Companion TestsSriram Kalpana0Wan-Ying Lin1Yu-Chiang Wang2Yiwen Fu3Hsin-Yao Wang4Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333423, TaiwanDepartment of Medicine, University of California San Diego, San Diego, CA 92093, USADepartment of Medicine, Harvard Medical School, Boston, MA 02115, USADepartment of Medicine, Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA 95051, USADepartment of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333423, TaiwanNew antimicrobial approaches are essential to counter antimicrobial resistance. The drug development pipeline is exhausted with the emergence of resistance, resulting in unsuccessful trials. The lack of an effective drug developed from the conventional drug portfolio has mandated the introspection into the list of potentially effective unconventional alternate antimicrobial molecules. Alternate therapies with clinically explicable forms include monoclonal antibodies, antimicrobial peptides, aptamers, and phages. Clinical diagnostics optimize the drug delivery. In the era of diagnostic-based applications, it is logical to draw diagnostic-based treatment for infectious diseases. Selection criteria of alternate therapeutics in infectious diseases include detection, monitoring of response, and resistance mechanism identification. Integrating these diagnostic applications is disruptive to the traditional therapeutic development. The challenges and mitigation methods need to be noted. Applying the goals of clinical pharmacokinetics that include enhancing efficacy and decreasing toxicity of drug therapy, this review analyses the strong correlation of alternate antimicrobial therapeutics in infectious diseases. The relationship between drug concentration and the resulting effect defined by the pharmacodynamic parameters are also analyzed. This review analyzes the perspectives of aligning diagnostic initiatives with the use of alternate therapeutics, with a particular focus on companion diagnostic applications in infectious diseases.https://www.mdpi.com/2075-4418/13/15/2490antimicrobial resistanceantimicrobial peptidesaptamerscompanion diagnosticsbacteriophagescompanion diagnostics |
| spellingShingle | Sriram Kalpana Wan-Ying Lin Yu-Chiang Wang Yiwen Fu Hsin-Yao Wang Alternate Antimicrobial Therapies and Their Companion Tests Diagnostics antimicrobial resistance antimicrobial peptides aptamers companion diagnostics bacteriophages companion diagnostics |
| title | Alternate Antimicrobial Therapies and Their Companion Tests |
| title_full | Alternate Antimicrobial Therapies and Their Companion Tests |
| title_fullStr | Alternate Antimicrobial Therapies and Their Companion Tests |
| title_full_unstemmed | Alternate Antimicrobial Therapies and Their Companion Tests |
| title_short | Alternate Antimicrobial Therapies and Their Companion Tests |
| title_sort | alternate antimicrobial therapies and their companion tests |
| topic | antimicrobial resistance antimicrobial peptides aptamers companion diagnostics bacteriophages companion diagnostics |
| url | https://www.mdpi.com/2075-4418/13/15/2490 |
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