Effects of Pomegranate Seed and Peel Methanolic Extracts on Methotrexate-Induced Hepatotoxicity in Rats

Effects of Pomegranate Seed and Peel Methanolic Extracts on Methotrexate-Induced Hepatotoxicity in Rats

Background: Hepatotoxicity—the most important side effect of the Methotrexate (MTX)—seems to relate to the generation of reactive oxygen species. Pomegranate has high anti-oxidant capacities. We studied if MTX-induced hepatotoxicity can be protected by pomegranate peel and seed methanolic extracts (...

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Bibliographic Details
Main Authors: Farideh Doostan, Mehran Mesgari Abbasi, Monireh Khordadmehr, Farnoush Fallah, Azin Behrouzy
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2019-06-01
Series:Pharmaceutical Sciences
Subjects:
Hepatotoxicity
Methotrexate
Pomegranate
Rat
Online Access:https://ps.tbzmed.ac.ir/PDF/PHARM_16022_20181022125218

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