A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations.

A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations.

To develop a comprehensive overview of copy number aberrations (CNAs) in stage-II/III colorectal cancer (CRC), we characterized 302 tumors from the PETACC-3 clinical trial. Microsatellite-stable (MSS) samples (n = 269) had 66 minimal common CNA regions, with frequent gains on 20 q (72.5%), 7 (41.8%)...

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Bibliographic Details
Main Authors: Tao Xie, Giovanni D' Ario, John R Lamb, Eric Martin, Kai Wang, Sabine Tejpar, Mauro Delorenzi, Fred T Bosman, Arnaud D Roth, Pu Yan, Stephanie Bougel, Antonio Fabio Di Narzo, Vlad Popovici, Eva Budinská, Mao Mao, Scott L Weinrich, Paul A Rejto, J Graeme Hodgson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3409212?pdf=render

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