Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study
<p>Abstract</p> <p>Background</p> <p>Previous studies of mechanical strain anomalies in myocardial infarction (MI) have been largely limited to analysis of one-dimensional (1D) and two-dimensional (2D) strain parameters. Advances in cardiovascular magnetic resonance (CM...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2012-12-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://www.jcmr-online.com/content/14/1/85 |
| _version_ | 1797203621861916672 |
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| author | Soleimanifard Sahar Abd-Elmoniem Khaled Z Sasano Tetsuo Agarwal Harsh K Abraham M Roselle Abraham Theodore P Prince Jerry L |
| author_facet | Soleimanifard Sahar Abd-Elmoniem Khaled Z Sasano Tetsuo Agarwal Harsh K Abraham M Roselle Abraham Theodore P Prince Jerry L |
| author_sort | Soleimanifard Sahar |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Previous studies of mechanical strain anomalies in myocardial infarction (MI) have been largely limited to analysis of one-dimensional (1D) and two-dimensional (2D) strain parameters. Advances in cardiovascular magnetic resonance (CMR) methods now permit a complete three-dimensional (3D) interrogation of myocardial regional strain. The aim of this study was to investigate the incremental value of CMR-based 3D strain and to test the hypothesis that 3D strain is superior to 1D or 2D strain analysis in the assessment of viability using a porcine model of infarction.</p> <p>Methods</p> <p>Infarction was induced surgically in 20 farm pigs. Cine, late gadolinium enhancement, and CMR tagging images were acquired at 11 days before (<it>baseline</it>), and 11 days (<it>early</it>) and 1 month (<it>late</it>) after induction of infarct. Harmonic phase analysis was performed to measure circumferential, longitudinal, and radial strains in myocardial segments, which were defined based on the transmurality of delayed enhancement. Univariate, bivariate, and multivariate logistic regression models of strain parameters were created and analyzed to compare the overall diagnostic accuracy of 3D strain analysis with 1D and 2D analyses in identifying the infarct and its adjacent regions from healthy myocardium.</p> <p>Results</p> <p>3D strain differed significantly in infarct, adjacent, and remote segments (p < 0.05) at early and late post-MI. In univariate, bivariate, and multivariate analyses, circumferential, longitudinal, and radial strains were significant factors (p < 0.001) in differentiation of infarct and adjacent segments from baseline values. In identification of adjacent segments, receiver operating characteristic analysis using the 3D strain multivariate model demonstrated a significant improvement (p < 0.01) in overall diagnostic accuracy in comparison with 2D (circumferential and radial) and 1D (circumferential) models (3D: 96%, 2D: 81%, and 1D: 71%). A similar trend was observed in identification of infarct segments.</p> <p>Conclusions</p> <p>Cumulative 3D strain information accurately identifies infarcts and their neighboring regions from healthy myocardium. The 3D interrogation of myocardial contractility provides incremental diagnostic accuracy in delineating the dysfunctional and nonviable myocardium in comparison with 1D or 2D quantification of strain. The infarct neighboring regions are the major beneficiaries of the 3D assessment of regional strain.</p> |
| first_indexed | 2024-04-24T08:22:15Z |
| format | Article |
| id | doaj.art-27458163a293460b94a2fc91a4e03383 |
| institution | Directory Open Access Journal |
| issn | 1097-6647 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:22:15Z |
| publishDate | 2012-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-27458163a293460b94a2fc91a4e033832024-04-17T00:27:21ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2012-12-011418510.1186/1532-429X-14-85Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging studySoleimanifard SaharAbd-Elmoniem Khaled ZSasano TetsuoAgarwal Harsh KAbraham M RoselleAbraham Theodore PPrince Jerry L<p>Abstract</p> <p>Background</p> <p>Previous studies of mechanical strain anomalies in myocardial infarction (MI) have been largely limited to analysis of one-dimensional (1D) and two-dimensional (2D) strain parameters. Advances in cardiovascular magnetic resonance (CMR) methods now permit a complete three-dimensional (3D) interrogation of myocardial regional strain. The aim of this study was to investigate the incremental value of CMR-based 3D strain and to test the hypothesis that 3D strain is superior to 1D or 2D strain analysis in the assessment of viability using a porcine model of infarction.</p> <p>Methods</p> <p>Infarction was induced surgically in 20 farm pigs. Cine, late gadolinium enhancement, and CMR tagging images were acquired at 11 days before (<it>baseline</it>), and 11 days (<it>early</it>) and 1 month (<it>late</it>) after induction of infarct. Harmonic phase analysis was performed to measure circumferential, longitudinal, and radial strains in myocardial segments, which were defined based on the transmurality of delayed enhancement. Univariate, bivariate, and multivariate logistic regression models of strain parameters were created and analyzed to compare the overall diagnostic accuracy of 3D strain analysis with 1D and 2D analyses in identifying the infarct and its adjacent regions from healthy myocardium.</p> <p>Results</p> <p>3D strain differed significantly in infarct, adjacent, and remote segments (p < 0.05) at early and late post-MI. In univariate, bivariate, and multivariate analyses, circumferential, longitudinal, and radial strains were significant factors (p < 0.001) in differentiation of infarct and adjacent segments from baseline values. In identification of adjacent segments, receiver operating characteristic analysis using the 3D strain multivariate model demonstrated a significant improvement (p < 0.01) in overall diagnostic accuracy in comparison with 2D (circumferential and radial) and 1D (circumferential) models (3D: 96%, 2D: 81%, and 1D: 71%). A similar trend was observed in identification of infarct segments.</p> <p>Conclusions</p> <p>Cumulative 3D strain information accurately identifies infarcts and their neighboring regions from healthy myocardium. The 3D interrogation of myocardial contractility provides incremental diagnostic accuracy in delineating the dysfunctional and nonviable myocardium in comparison with 1D or 2D quantification of strain. The infarct neighboring regions are the major beneficiaries of the 3D assessment of regional strain.</p>http://www.jcmr-online.com/content/14/1/85Magnetic resonance taggingHarmonic phase analysisThree-dimensional regional strainMyocardial infarctionDiagnostic accuracy |
| spellingShingle | Soleimanifard Sahar Abd-Elmoniem Khaled Z Sasano Tetsuo Agarwal Harsh K Abraham M Roselle Abraham Theodore P Prince Jerry L Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study Journal of Cardiovascular Magnetic Resonance Magnetic resonance tagging Harmonic phase analysis Three-dimensional regional strain Myocardial infarction Diagnostic accuracy |
| title | Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study |
| title_full | Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study |
| title_fullStr | Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study |
| title_full_unstemmed | Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study |
| title_short | Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study |
| title_sort | three dimensional regional strain analysis in porcine myocardial infarction a 3t magnetic resonance tagging study |
| topic | Magnetic resonance tagging Harmonic phase analysis Three-dimensional regional strain Myocardial infarction Diagnostic accuracy |
| url | http://www.jcmr-online.com/content/14/1/85 |
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