Parkinson’s Disease With Depression: The Correlations Between Neuroinflammatory Factors and Neurotransmitters in Cerebrospinal Fluid
Background: To explore the changes of neuroinflammatory factors in cerebrospinal fluid (CSF) and their correlation with monoamine neurotransmitters in Parkinson’s disease (PD) with depression (PD-D) patients.Methods: Neuroinflammatory factors and neurotransmitters in CSF were measured and compared b...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2020.574776/full |
| _version_ | 1828784285034741760 |
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| author | Teng-hong Lian Peng Guo Ya-nan Zhang Jing-hui Li Li-xia Li Du-yu Ding Da-ning Li Wei-jiao Zhang Hui-ying Guan Xiao-min Wang Wei Zhang Wei Zhang Wei Zhang Wei Zhang |
| author_facet | Teng-hong Lian Peng Guo Ya-nan Zhang Jing-hui Li Li-xia Li Du-yu Ding Da-ning Li Wei-jiao Zhang Hui-ying Guan Xiao-min Wang Wei Zhang Wei Zhang Wei Zhang Wei Zhang |
| author_sort | Teng-hong Lian |
| collection | DOAJ |
| description | Background: To explore the changes of neuroinflammatory factors in cerebrospinal fluid (CSF) and their correlation with monoamine neurotransmitters in Parkinson’s disease (PD) with depression (PD-D) patients.Methods: Neuroinflammatory factors and neurotransmitters in CSF were measured and compared between PD with no depression (PD-ND) and PD-D groups. The relationship between PD-D and neuroinflammatory factors was studied by binary logistic regression equation, and the related factors of PD-D were adjusted. The correlations of the levels of neuroinflammatory factors and neurotransmitters in PD-D group were analyzed.Results: The levels of tumor necrosis factor (TNF)-α in CSF from PD-D group were significantly higher and there were no significant differences in the levels of interleukin-1β, prostaglandin (PG) E2, hydrogen peroxide (H2O2), and nitric oxide (NO). The 24-item Hamilton Depression Scale (HAMD-24) score was positively correlated with the level of TNF-α in CSF. Binary logistic regression showed that the OR of CSF TNF-α level was 1.035 (95% CI 1.002–1.069). The level of dopamine (DA) in CSF of PD-D group was significantly lower than that in PD-ND group. TNF-α level was negatively correlated with DA level in CSF from PD patients (r = −0.320, P = 0.003).Conclusions: Neuroinflammatory factors, especially TNF-α, may play an important role in PD-D. It may cause damage to DA neurons and lead to the depletion of DA, which is related to the occurrence and development of PD-D. |
| first_indexed | 2024-12-11T23:28:47Z |
| format | Article |
| id | doaj.art-2745ead2734f4a6da2fc4863e76d9a9e |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T23:28:47Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-2745ead2734f4a6da2fc4863e76d9a9e2022-12-22T00:46:06ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-10-011210.3389/fnagi.2020.574776574776Parkinson’s Disease With Depression: The Correlations Between Neuroinflammatory Factors and Neurotransmitters in Cerebrospinal FluidTeng-hong Lian0Peng Guo1Ya-nan Zhang2Jing-hui Li3Li-xia Li4Du-yu Ding5Da-ning Li6Wei-jiao Zhang7Hui-ying Guan8Xiao-min Wang9Wei Zhang10Wei Zhang11Wei Zhang12Wei Zhang13Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Blood Transfusion, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of General Internal Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Physiology, Capital Medical University, Beijing, ChinaCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory on Parkinson Disease, Beijing, ChinaBackground: To explore the changes of neuroinflammatory factors in cerebrospinal fluid (CSF) and their correlation with monoamine neurotransmitters in Parkinson’s disease (PD) with depression (PD-D) patients.Methods: Neuroinflammatory factors and neurotransmitters in CSF were measured and compared between PD with no depression (PD-ND) and PD-D groups. The relationship between PD-D and neuroinflammatory factors was studied by binary logistic regression equation, and the related factors of PD-D were adjusted. The correlations of the levels of neuroinflammatory factors and neurotransmitters in PD-D group were analyzed.Results: The levels of tumor necrosis factor (TNF)-α in CSF from PD-D group were significantly higher and there were no significant differences in the levels of interleukin-1β, prostaglandin (PG) E2, hydrogen peroxide (H2O2), and nitric oxide (NO). The 24-item Hamilton Depression Scale (HAMD-24) score was positively correlated with the level of TNF-α in CSF. Binary logistic regression showed that the OR of CSF TNF-α level was 1.035 (95% CI 1.002–1.069). The level of dopamine (DA) in CSF of PD-D group was significantly lower than that in PD-ND group. TNF-α level was negatively correlated with DA level in CSF from PD patients (r = −0.320, P = 0.003).Conclusions: Neuroinflammatory factors, especially TNF-α, may play an important role in PD-D. It may cause damage to DA neurons and lead to the depletion of DA, which is related to the occurrence and development of PD-D.https://www.frontiersin.org/articles/10.3389/fnagi.2020.574776/fullParkinson’s diseasedepressionneuroinflammatory factorsneurotransmitterscerebrospinal fluid |
| spellingShingle | Teng-hong Lian Peng Guo Ya-nan Zhang Jing-hui Li Li-xia Li Du-yu Ding Da-ning Li Wei-jiao Zhang Hui-ying Guan Xiao-min Wang Wei Zhang Wei Zhang Wei Zhang Wei Zhang Parkinson’s Disease With Depression: The Correlations Between Neuroinflammatory Factors and Neurotransmitters in Cerebrospinal Fluid Frontiers in Aging Neuroscience Parkinson’s disease depression neuroinflammatory factors neurotransmitters cerebrospinal fluid |
| title | Parkinson’s Disease With Depression: The Correlations Between Neuroinflammatory Factors and Neurotransmitters in Cerebrospinal Fluid |
| title_full | Parkinson’s Disease With Depression: The Correlations Between Neuroinflammatory Factors and Neurotransmitters in Cerebrospinal Fluid |
| title_fullStr | Parkinson’s Disease With Depression: The Correlations Between Neuroinflammatory Factors and Neurotransmitters in Cerebrospinal Fluid |
| title_full_unstemmed | Parkinson’s Disease With Depression: The Correlations Between Neuroinflammatory Factors and Neurotransmitters in Cerebrospinal Fluid |
| title_short | Parkinson’s Disease With Depression: The Correlations Between Neuroinflammatory Factors and Neurotransmitters in Cerebrospinal Fluid |
| title_sort | parkinson s disease with depression the correlations between neuroinflammatory factors and neurotransmitters in cerebrospinal fluid |
| topic | Parkinson’s disease depression neuroinflammatory factors neurotransmitters cerebrospinal fluid |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2020.574776/full |
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