Effect of Denosumab Therapy on Pain Level in Diffuse Sclerosing Osteomyelitis of the Mandible: a Case Report
This is the first case report where two patients were under uniform denosumab administration protocol in diffuse sclerosing osteomyelitis (DSO) treatment and were closely monitored for 18 months. Objectives: This study aimed to describe the beneficial effects of denosumab in DSO treatment as well as...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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University of Zagreb. School of Dental Medicine
2023-01-01
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| Series: | Acta Stomatologica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/428682 |
| _version_ | 1827281839656534016 |
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| author | Daniel Jerković Kristian Jerković Antonella Lesin Ana Poljičanin Ivan Galić |
| author_facet | Daniel Jerković Kristian Jerković Antonella Lesin Ana Poljičanin Ivan Galić |
| author_sort | Daniel Jerković |
| collection | DOAJ |
| description | This is the first case report where two patients were under uniform denosumab administration protocol in diffuse sclerosing osteomyelitis (DSO) treatment and were closely monitored for 18 months. Objectives: This study aimed to describe the beneficial effects of denosumab in DSO treatment as well as pain relief and the significant lack of long-term use due to poorer outcomes after repeated use. DSO of the jaw is a poorly understood rare chronic disease the treatment of which is still very challenging despite a rapid development of medicine. Different medical treatments have been pro-posed without any significant long-lasting success. Bisphosphonates have offered substantial clinical benefit in DSO therapy, but due to harmful pharmacodynamic properties, denosumab therapy has been used to replace bisphosphonate therapy. Patients had a reduction in pain intensity with each subsequent application of denosumab but with less success than the first administration of de-nosumab. This case report has shown that denosumab could be a promising conservative treatment option for pain treatment in patients suffering from DSO. |
| first_indexed | 2024-04-24T09:07:58Z |
| format | Article |
| id | doaj.art-2747d0d2434948fa8b9d719fc7ca12a8 |
| institution | Directory Open Access Journal |
| issn | 0001-7019 1846-0410 |
| language | English |
| last_indexed | 2024-04-24T09:07:58Z |
| publishDate | 2023-01-01 |
| publisher | University of Zagreb. School of Dental Medicine |
| record_format | Article |
| series | Acta Stomatologica Croatica |
| spelling | doaj.art-2747d0d2434948fa8b9d719fc7ca12a82024-04-15T18:22:30ZengUniversity of Zagreb. School of Dental MedicineActa Stomatologica Croatica0001-70191846-04102023-01-01571626910.15644/asc57/1/7Effect of Denosumab Therapy on Pain Level in Diffuse Sclerosing Osteomyelitis of the Mandible: a Case ReportDaniel Jerković0Kristian Jerković1Antonella Lesin2Ana Poljičanin3Ivan Galić4Department of Maxillofacial Surgery, Clinical Hospital Centre Split, Department of Oral Surgery, School of Medicine, University of Split, CroatiaClinical Department of Diagnostic and Interventional Radiology, Clinical Hospital Centre Split, CroatiaDepartment of Maxillofacial Surgery, Clinical Hospital Centre Split, Department of Oral Surgery, School of Medicine, University of Split, CroatiaInstitute of Physical Medicine and Rehabilitation with Rheumatology University Hospital of Split, University Department of Health Studies University of Split, CroatiaDepartment of Maxillofacial Surgery, Clinical Hospital Centre Split, Department of Oral Surgery, School of Medicine, University of Split, CroatiaThis is the first case report where two patients were under uniform denosumab administration protocol in diffuse sclerosing osteomyelitis (DSO) treatment and were closely monitored for 18 months. Objectives: This study aimed to describe the beneficial effects of denosumab in DSO treatment as well as pain relief and the significant lack of long-term use due to poorer outcomes after repeated use. DSO of the jaw is a poorly understood rare chronic disease the treatment of which is still very challenging despite a rapid development of medicine. Different medical treatments have been pro-posed without any significant long-lasting success. Bisphosphonates have offered substantial clinical benefit in DSO therapy, but due to harmful pharmacodynamic properties, denosumab therapy has been used to replace bisphosphonate therapy. Patients had a reduction in pain intensity with each subsequent application of denosumab but with less success than the first administration of de-nosumab. This case report has shown that denosumab could be a promising conservative treatment option for pain treatment in patients suffering from DSO.https://hrcak.srce.hr/file/428682OsteomyelitisMandiblePain ManagementDenosumabPainSclerosing Osteomyelitis |
| spellingShingle | Daniel Jerković Kristian Jerković Antonella Lesin Ana Poljičanin Ivan Galić Effect of Denosumab Therapy on Pain Level in Diffuse Sclerosing Osteomyelitis of the Mandible: a Case Report Acta Stomatologica Croatica Osteomyelitis Mandible Pain Management Denosumab Pain Sclerosing Osteomyelitis |
| title | Effect of Denosumab Therapy on Pain Level in Diffuse Sclerosing Osteomyelitis of the Mandible: a Case Report |
| title_full | Effect of Denosumab Therapy on Pain Level in Diffuse Sclerosing Osteomyelitis of the Mandible: a Case Report |
| title_fullStr | Effect of Denosumab Therapy on Pain Level in Diffuse Sclerosing Osteomyelitis of the Mandible: a Case Report |
| title_full_unstemmed | Effect of Denosumab Therapy on Pain Level in Diffuse Sclerosing Osteomyelitis of the Mandible: a Case Report |
| title_short | Effect of Denosumab Therapy on Pain Level in Diffuse Sclerosing Osteomyelitis of the Mandible: a Case Report |
| title_sort | effect of denosumab therapy on pain level in diffuse sclerosing osteomyelitis of the mandible a case report |
| topic | Osteomyelitis Mandible Pain Management Denosumab Pain Sclerosing Osteomyelitis |
| url | https://hrcak.srce.hr/file/428682 |
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