The Effect of Anthocyanins from <i>Dioscorea alata</i> L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland
(1) Background: The mammary glands of the perinatal goats are susceptible to reactive oxygen species (ROS) leading to oxidative injury. Although <i>Dioscorea alata</i> L. is rich in anthocyanins with high safety and excellent free-radical-scavenging ability, the effect and mechanism of &...
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MDPI AG
2022-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/23/3320 |
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| author | Yuanxin Zhang Huiyu Shi Yanhong Yun Haibo Feng Xuemei Wang |
| author_facet | Yuanxin Zhang Huiyu Shi Yanhong Yun Haibo Feng Xuemei Wang |
| author_sort | Yuanxin Zhang |
| collection | DOAJ |
| description | (1) Background: The mammary glands of the perinatal goats are susceptible to reactive oxygen species (ROS) leading to oxidative injury. Although <i>Dioscorea alata</i> L. is rich in anthocyanins with high safety and excellent free-radical-scavenging ability, the effect and mechanism of <i>Dioscorea alata</i> L. anthocyanins (DAC) on the antioxidant capacity of the black Hainan goat has been the subject of few studies to date; (2) Methods: For this reason, feeding experiments were performed by feeding experimental diets, and the pre-protective capacity of DAC on goat mammary epithelial cells was explored on the basis of the established model of H<sub>2</sub>O<sub>2</sub> injury; (3) Results: As well as altering rumen fermentation parameters in perinatal female goats, dietary challenge also improves antioxidant capacity in their blood and milk. thereby enhancing children’s antioxidant capacity and increasing their resistance to oxidative stress. However, we also found that DAC pretreatment was capable of activating both Nrf2 and MAPK/JNK pathways, which results in enhanced antioxidase activity and elimination of ROS; (4) Conclusions: Together, these findings suggest that DAC may have a pre-protective role on perinatal Hainan black goats through the regulation of Nrf2 and MAPK/JNK pathways in GMEC. |
| first_indexed | 2024-03-09T17:55:00Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T17:55:00Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-27495d7dafc44ba0a53ce858704906ed2023-11-24T10:25:10ZengMDPI AGAnimals2076-26152022-11-011223332010.3390/ani12233320The Effect of Anthocyanins from <i>Dioscorea alata</i> L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary GlandYuanxin Zhang0Huiyu Shi1Yanhong Yun2Haibo Feng3Xuemei Wang4College of Animal Science and Technology, Hainan University, Haikou 570228, ChinaCollege of Animal Science and Technology, Hainan University, Haikou 570228, ChinaCollege of Animal Science and Technology, Hainan University, Haikou 570228, ChinaCollege of Animal Science and Technology, Hainan University, Haikou 570228, ChinaCollege of Animal Science and Technology, Hainan University, Haikou 570228, China(1) Background: The mammary glands of the perinatal goats are susceptible to reactive oxygen species (ROS) leading to oxidative injury. Although <i>Dioscorea alata</i> L. is rich in anthocyanins with high safety and excellent free-radical-scavenging ability, the effect and mechanism of <i>Dioscorea alata</i> L. anthocyanins (DAC) on the antioxidant capacity of the black Hainan goat has been the subject of few studies to date; (2) Methods: For this reason, feeding experiments were performed by feeding experimental diets, and the pre-protective capacity of DAC on goat mammary epithelial cells was explored on the basis of the established model of H<sub>2</sub>O<sub>2</sub> injury; (3) Results: As well as altering rumen fermentation parameters in perinatal female goats, dietary challenge also improves antioxidant capacity in their blood and milk. thereby enhancing children’s antioxidant capacity and increasing their resistance to oxidative stress. However, we also found that DAC pretreatment was capable of activating both Nrf2 and MAPK/JNK pathways, which results in enhanced antioxidase activity and elimination of ROS; (4) Conclusions: Together, these findings suggest that DAC may have a pre-protective role on perinatal Hainan black goats through the regulation of Nrf2 and MAPK/JNK pathways in GMEC.https://www.mdpi.com/2076-2615/12/23/3320perinatalHainan black goats<i>Dioscorea alata</i> L. anthocyaninoxidative damagepre-protection |
| spellingShingle | Yuanxin Zhang Huiyu Shi Yanhong Yun Haibo Feng Xuemei Wang The Effect of Anthocyanins from <i>Dioscorea alata</i> L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland Animals perinatal Hainan black goats <i>Dioscorea alata</i> L. anthocyanin oxidative damage pre-protection |
| title | The Effect of Anthocyanins from <i>Dioscorea alata</i> L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland |
| title_full | The Effect of Anthocyanins from <i>Dioscorea alata</i> L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland |
| title_fullStr | The Effect of Anthocyanins from <i>Dioscorea alata</i> L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland |
| title_full_unstemmed | The Effect of Anthocyanins from <i>Dioscorea alata</i> L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland |
| title_short | The Effect of Anthocyanins from <i>Dioscorea alata</i> L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland |
| title_sort | effect of anthocyanins from i dioscorea alata i l on antioxidant properties of perinatal hainan black goats and its possible mechanism in the mammary gland |
| topic | perinatal Hainan black goats <i>Dioscorea alata</i> L. anthocyanin oxidative damage pre-protection |
| url | https://www.mdpi.com/2076-2615/12/23/3320 |
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