Therapeutic Effects of Prolonged Release Melatonin (Circadin) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old
Objectives Bladder storage symptoms including nocturia is the most common cause of sleep disturbance in all age groups. Sleep disturbance is also a main cause of nocturia so that sleep recovery can clinically improve nocturia. Melatonin has main action to induce sleep and additional effects of smoot...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2020-12-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc035-02-02.pdf |
| _version_ | 1797991466713219072 |
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| author | Min Jung Park Seon Young Seo Hyun Jun Park Jih Hoon Park Mi Young Lim Nam Cheol Park |
| author_facet | Min Jung Park Seon Young Seo Hyun Jun Park Jih Hoon Park Mi Young Lim Nam Cheol Park |
| author_sort | Min Jung Park |
| collection | DOAJ |
| description | Objectives Bladder storage symptoms including nocturia is the most common cause of sleep disturbance in all age groups. Sleep disturbance is also a main cause of nocturia so that sleep recovery can clinically improve nocturia. Melatonin has main action to induce sleep and additional effects of smooth muscle relaxation, free radical scavenging, anti-inflammation, et cetera. This study was evaluated the improvement of sleep quality after administrating prolonged-release melatonin in elderly patients with overactive bladder and chronic insomnia. Methods This clinical trial was performed with a randomized single open study. Thirty-seven patients with overactive bladder and chronic insomnia were initially enrolled in this study. After 4 or 12 weeks treating with 2 mg of prolonged-release melatonin, clinical outcomes were evaluated with OABSS, IPSS, PSQI and WHO 5 well-being index. Results Of the 37 patients, 34 (91.9%) were included in the ITT group and 26 (76.5%) in the PP group. In the primary outcome of PP group, significant improvements were observed in total OABSS and nocturia frequencies at 12 weeks, respectively. Secondary outcome measurement including in voiding, storage symptoms, and total IPSS scores showed the improvement at 4 and 12 weeks and in total and sleep quality PSQI scores at 12 weeks, and in quality of life scores of the WHO 5 well-being index at 12 weeks. Only one (3.8%) adverse event was observed. Conclusions These results suggest clearly that prolonged-release melatonin in elderly patients with overactive bladder and chronic insomnia has the potential to control concomitant voiding and sleep difficulty. |
| first_indexed | 2024-04-11T08:52:44Z |
| format | Article |
| id | doaj.art-27497e8fe013466e814bea641b01a7a7 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-11T08:52:44Z |
| publishDate | 2020-12-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-27497e8fe013466e814bea641b01a7a72022-12-22T04:33:27ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242020-12-0135210111310.7180/kmj.2020.35.2.101224Therapeutic Effects of Prolonged Release Melatonin (Circadin) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years OldMin Jung Park0Seon Young Seo1Hyun Jun Park2Jih Hoon Park3Mi Young Lim4Nam Cheol Park5 The Korea Institute for Public Sperm Bank, Busan, Korea The Korea Institute for Public Sperm Bank, Busan, Korea Department of Urology, Pusan National University School of Medicine, Busan, Korea Department of Urology, Pusan National University School of Medicine, Busan, Korea Department of Urology, Pusan National University School of Medicine, Busan, Korea The Korea Institute for Public Sperm Bank, Busan, KoreaObjectives Bladder storage symptoms including nocturia is the most common cause of sleep disturbance in all age groups. Sleep disturbance is also a main cause of nocturia so that sleep recovery can clinically improve nocturia. Melatonin has main action to induce sleep and additional effects of smooth muscle relaxation, free radical scavenging, anti-inflammation, et cetera. This study was evaluated the improvement of sleep quality after administrating prolonged-release melatonin in elderly patients with overactive bladder and chronic insomnia. Methods This clinical trial was performed with a randomized single open study. Thirty-seven patients with overactive bladder and chronic insomnia were initially enrolled in this study. After 4 or 12 weeks treating with 2 mg of prolonged-release melatonin, clinical outcomes were evaluated with OABSS, IPSS, PSQI and WHO 5 well-being index. Results Of the 37 patients, 34 (91.9%) were included in the ITT group and 26 (76.5%) in the PP group. In the primary outcome of PP group, significant improvements were observed in total OABSS and nocturia frequencies at 12 weeks, respectively. Secondary outcome measurement including in voiding, storage symptoms, and total IPSS scores showed the improvement at 4 and 12 weeks and in total and sleep quality PSQI scores at 12 weeks, and in quality of life scores of the WHO 5 well-being index at 12 weeks. Only one (3.8%) adverse event was observed. Conclusions These results suggest clearly that prolonged-release melatonin in elderly patients with overactive bladder and chronic insomnia has the potential to control concomitant voiding and sleep difficulty.http://www.kosinmedj.org/upload/pdf/ksmc035-02-02.pdfinsomniamelatoninnocturiaoveractive bladder |
| spellingShingle | Min Jung Park Seon Young Seo Hyun Jun Park Jih Hoon Park Mi Young Lim Nam Cheol Park Therapeutic Effects of Prolonged Release Melatonin (Circadin) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old Kosin Medical Journal insomnia melatonin nocturia overactive bladder |
| title | Therapeutic Effects of Prolonged Release Melatonin (Circadin) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old |
| title_full | Therapeutic Effects of Prolonged Release Melatonin (Circadin) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old |
| title_fullStr | Therapeutic Effects of Prolonged Release Melatonin (Circadin) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old |
| title_full_unstemmed | Therapeutic Effects of Prolonged Release Melatonin (Circadin) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old |
| title_short | Therapeutic Effects of Prolonged Release Melatonin (Circadin) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old |
| title_sort | therapeutic effects of prolonged release melatonin circadin in patients with overactive bladder and chronic insomnia in more than 55 years old |
| topic | insomnia melatonin nocturia overactive bladder |
| url | http://www.kosinmedj.org/upload/pdf/ksmc035-02-02.pdf |
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