Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the...

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Main Authors: Christina D. Kwon, Raveena Khanna, Kyle A. Williams, Madan M. Kwatra, Shawn G. Kwatra
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Medicines
Subjects:
Online Access:https://www.mdpi.com/2305-6320/6/4/97
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author Christina D. Kwon
Raveena Khanna
Kyle A. Williams
Madan M. Kwatra
Shawn G. Kwatra
author_facet Christina D. Kwon
Raveena Khanna
Kyle A. Williams
Madan M. Kwatra
Shawn G. Kwatra
author_sort Christina D. Kwon
collection DOAJ
description Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the pathogenesis of PN. There are several associated etiologic factors thought to be associated with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. We conducted a systematic literature review to evaluate the clinical presentation, diagnosis, and etiologic factors of PN. In this review, we discuss common differential diagnoses of PN and recommend an evidence-based, standardized diagnostic evaluation for those with suspected PN.
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spelling doaj.art-274a5f75a78b4bd1bb9040ce049ffa602022-12-21T19:53:17ZengMDPI AGMedicines2305-63202019-09-01649710.3390/medicines6040097medicines6040097Diagnostic Workup and Evaluation of Patients with Prurigo NodularisChristina D. Kwon0Raveena Khanna1Kyle A. Williams2Madan M. Kwatra3Shawn G. Kwatra4Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USAPrurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the pathogenesis of PN. There are several associated etiologic factors thought to be associated with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. We conducted a systematic literature review to evaluate the clinical presentation, diagnosis, and etiologic factors of PN. In this review, we discuss common differential diagnoses of PN and recommend an evidence-based, standardized diagnostic evaluation for those with suspected PN.https://www.mdpi.com/2305-6320/6/4/97medical dermatologyprurigo nodularissystematic reviewitchpruritus
spellingShingle Christina D. Kwon
Raveena Khanna
Kyle A. Williams
Madan M. Kwatra
Shawn G. Kwatra
Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis
Medicines
medical dermatology
prurigo nodularis
systematic review
itch
pruritus
title Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis
title_full Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis
title_fullStr Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis
title_full_unstemmed Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis
title_short Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis
title_sort diagnostic workup and evaluation of patients with prurigo nodularis
topic medical dermatology
prurigo nodularis
systematic review
itch
pruritus
url https://www.mdpi.com/2305-6320/6/4/97
work_keys_str_mv AT christinadkwon diagnosticworkupandevaluationofpatientswithprurigonodularis
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AT madanmkwatra diagnosticworkupandevaluationofpatientswithprurigonodularis
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