Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-09-01
|
Series: | Medicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2305-6320/6/4/97 |
_version_ | 1818932622144831488 |
---|---|
author | Christina D. Kwon Raveena Khanna Kyle A. Williams Madan M. Kwatra Shawn G. Kwatra |
author_facet | Christina D. Kwon Raveena Khanna Kyle A. Williams Madan M. Kwatra Shawn G. Kwatra |
author_sort | Christina D. Kwon |
collection | DOAJ |
description | Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the pathogenesis of PN. There are several associated etiologic factors thought to be associated with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. We conducted a systematic literature review to evaluate the clinical presentation, diagnosis, and etiologic factors of PN. In this review, we discuss common differential diagnoses of PN and recommend an evidence-based, standardized diagnostic evaluation for those with suspected PN. |
first_indexed | 2024-12-20T04:35:24Z |
format | Article |
id | doaj.art-274a5f75a78b4bd1bb9040ce049ffa60 |
institution | Directory Open Access Journal |
issn | 2305-6320 |
language | English |
last_indexed | 2024-12-20T04:35:24Z |
publishDate | 2019-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Medicines |
spelling | doaj.art-274a5f75a78b4bd1bb9040ce049ffa602022-12-21T19:53:17ZengMDPI AGMedicines2305-63202019-09-01649710.3390/medicines6040097medicines6040097Diagnostic Workup and Evaluation of Patients with Prurigo NodularisChristina D. Kwon0Raveena Khanna1Kyle A. Williams2Madan M. Kwatra3Shawn G. Kwatra4Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USAPrurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the pathogenesis of PN. There are several associated etiologic factors thought to be associated with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. We conducted a systematic literature review to evaluate the clinical presentation, diagnosis, and etiologic factors of PN. In this review, we discuss common differential diagnoses of PN and recommend an evidence-based, standardized diagnostic evaluation for those with suspected PN.https://www.mdpi.com/2305-6320/6/4/97medical dermatologyprurigo nodularissystematic reviewitchpruritus |
spellingShingle | Christina D. Kwon Raveena Khanna Kyle A. Williams Madan M. Kwatra Shawn G. Kwatra Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis Medicines medical dermatology prurigo nodularis systematic review itch pruritus |
title | Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis |
title_full | Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis |
title_fullStr | Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis |
title_full_unstemmed | Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis |
title_short | Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis |
title_sort | diagnostic workup and evaluation of patients with prurigo nodularis |
topic | medical dermatology prurigo nodularis systematic review itch pruritus |
url | https://www.mdpi.com/2305-6320/6/4/97 |
work_keys_str_mv | AT christinadkwon diagnosticworkupandevaluationofpatientswithprurigonodularis AT raveenakhanna diagnosticworkupandevaluationofpatientswithprurigonodularis AT kyleawilliams diagnosticworkupandevaluationofpatientswithprurigonodularis AT madanmkwatra diagnosticworkupandevaluationofpatientswithprurigonodularis AT shawngkwatra diagnosticworkupandevaluationofpatientswithprurigonodularis |