Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing
Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/19/19/4333 |
| _version_ | 1811306614507962368 |
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| author | Maria Leilani Torres-Mapa Manmeet Singh Olga Simon Jose Louise Mapa Manan Machida Axel Günther Bernhard Roth Dag Heinemann Mitsuhiro Terakawa Alexander Heisterkamp |
| author_facet | Maria Leilani Torres-Mapa Manmeet Singh Olga Simon Jose Louise Mapa Manan Machida Axel Günther Bernhard Roth Dag Heinemann Mitsuhiro Terakawa Alexander Heisterkamp |
| author_sort | Maria Leilani Torres-Mapa |
| collection | DOAJ |
| description | Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices. |
| first_indexed | 2024-04-13T08:47:33Z |
| format | Article |
| id | doaj.art-274ad028373347b0b17176bde839d948 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T08:47:33Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-274ad028373347b0b17176bde839d9482022-12-22T02:53:36ZengMDPI AGSensors1424-82202019-10-011919433310.3390/s19194333s19194333Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical SensingMaria Leilani Torres-Mapa0Manmeet Singh1Olga Simon2Jose Louise Mapa3Manan Machida4Axel Günther5Bernhard Roth6Dag Heinemann7Mitsuhiro Terakawa8Alexander Heisterkamp9Institute of Quantum Optics, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, GermanyInstitute of Quantum Optics, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, GermanyLower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), 30625 Hannover, GermanyInstitute of Quantum Optics, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, GermanySchool of Integrated Design Engineering, Keio University, Yokohama 223-8522, JapanHannover Centre for Optical Technologies, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, GermanyHannover Centre for Optical Technologies, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, GermanyLower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), 30625 Hannover, GermanySchool of Integrated Design Engineering, Keio University, Yokohama 223-8522, JapanInstitute of Quantum Optics, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, GermanyHydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.https://www.mdpi.com/1424-8220/19/19/4333waveguidemicrofluidicsfluorescencehydrogels3d printing |
| spellingShingle | Maria Leilani Torres-Mapa Manmeet Singh Olga Simon Jose Louise Mapa Manan Machida Axel Günther Bernhard Roth Dag Heinemann Mitsuhiro Terakawa Alexander Heisterkamp Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing Sensors waveguide microfluidics fluorescence hydrogels 3d printing |
| title | Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing |
| title_full | Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing |
| title_fullStr | Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing |
| title_full_unstemmed | Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing |
| title_short | Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing |
| title_sort | fabrication of a monolithic lab on a chip platform with integrated hydrogel waveguides for chemical sensing |
| topic | waveguide microfluidics fluorescence hydrogels 3d printing |
| url | https://www.mdpi.com/1424-8220/19/19/4333 |
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