Probiotic Supplementation During Human Pregnancy Affects the Gut Microbiota and Immune Status
The consumption of probiotics and fermented foods has been very popular in recent decades. The primary aim of our study was to evaluate the effect of probiotics on the gut microbiota and the changes in inflammatory cytokines after an average of 6.7 weeks of probiotic administration among normal preg...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-07-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2019.00254/full |
| _version_ | 1818864482220244992 |
|---|---|
| author | Yuyi Chen Zhe Li Kian Deng Tye Huijuan Luo Xiaomei Tang Yu Liao Dongju Wang Juan Zhou Ping Yang Yimi Li Yingbing Su Xiaomin Xiao |
| author_facet | Yuyi Chen Zhe Li Kian Deng Tye Huijuan Luo Xiaomei Tang Yu Liao Dongju Wang Juan Zhou Ping Yang Yimi Li Yingbing Su Xiaomin Xiao |
| author_sort | Yuyi Chen |
| collection | DOAJ |
| description | The consumption of probiotics and fermented foods has been very popular in recent decades. The primary aim of our study was to evaluate the effect of probiotics on the gut microbiota and the changes in inflammatory cytokines after an average of 6.7 weeks of probiotic administration among normal pregnant women. Thirty-two healthy pregnant women at 32 weeks of gestation were recruited and divided into two groups. The probiotic group ingested combined probiotics until after birth. The base characteristics of the probiotics and control groups showed no significant differences. The structure of the fecal microbiota at the genus level varied during the third trimester, and administration of probiotics had no influence on the composition of the fecal microbiota however, many highly abundant taxa and core microbiota at the genus level changed in the probiotic group when compared to the control group. The analysis of cytokines showed that IL-5, IL-6, TNF-α, and GM-CSF had equal levels between the baseline and control groups but were significantly increased after probiotic administration (baseline = control < probiotics). Additionally, levels of IL-1β, IL-2, IL-12, and IFN-γ significantly increased among the three groups (baseline < control < probiotics). This result demonstrated that probiotics helped to shift the anti-inflammatory state to a pro-inflammatory state. The correlation analysis outcome suggested that the relationship between the microbiota and the cytokines was not strain-dependent. The gut microbiota varied during the third trimester. The probiotics demonstrated immunomodulation effects that helped to switch over to a pro-inflammatory immune state in the third trimester, which was important for labor. |
| first_indexed | 2024-12-19T10:32:21Z |
| format | Article |
| id | doaj.art-274b2108aac54b5fbbf3b7636086022d |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-19T10:32:21Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-274b2108aac54b5fbbf3b7636086022d2022-12-21T20:25:44ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882019-07-01910.3389/fcimb.2019.00254465558Probiotic Supplementation During Human Pregnancy Affects the Gut Microbiota and Immune StatusYuyi Chen0Zhe Li1Kian Deng Tye2Huijuan Luo3Xiaomei Tang4Yu Liao5Dongju Wang6Juan Zhou7Ping Yang8Yimi Li9Yingbing Su10Xiaomin Xiao11Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Clinical Medicine, International School of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaThe consumption of probiotics and fermented foods has been very popular in recent decades. The primary aim of our study was to evaluate the effect of probiotics on the gut microbiota and the changes in inflammatory cytokines after an average of 6.7 weeks of probiotic administration among normal pregnant women. Thirty-two healthy pregnant women at 32 weeks of gestation were recruited and divided into two groups. The probiotic group ingested combined probiotics until after birth. The base characteristics of the probiotics and control groups showed no significant differences. The structure of the fecal microbiota at the genus level varied during the third trimester, and administration of probiotics had no influence on the composition of the fecal microbiota however, many highly abundant taxa and core microbiota at the genus level changed in the probiotic group when compared to the control group. The analysis of cytokines showed that IL-5, IL-6, TNF-α, and GM-CSF had equal levels between the baseline and control groups but were significantly increased after probiotic administration (baseline = control < probiotics). Additionally, levels of IL-1β, IL-2, IL-12, and IFN-γ significantly increased among the three groups (baseline < control < probiotics). This result demonstrated that probiotics helped to shift the anti-inflammatory state to a pro-inflammatory state. The correlation analysis outcome suggested that the relationship between the microbiota and the cytokines was not strain-dependent. The gut microbiota varied during the third trimester. The probiotics demonstrated immunomodulation effects that helped to switch over to a pro-inflammatory immune state in the third trimester, which was important for labor.https://www.frontiersin.org/article/10.3389/fcimb.2019.00254/fullpregnancyprobioticsimmunomodulationmachine learninginteraction network |
| spellingShingle | Yuyi Chen Zhe Li Kian Deng Tye Huijuan Luo Xiaomei Tang Yu Liao Dongju Wang Juan Zhou Ping Yang Yimi Li Yingbing Su Xiaomin Xiao Probiotic Supplementation During Human Pregnancy Affects the Gut Microbiota and Immune Status Frontiers in Cellular and Infection Microbiology pregnancy probiotics immunomodulation machine learning interaction network |
| title | Probiotic Supplementation During Human Pregnancy Affects the Gut Microbiota and Immune Status |
| title_full | Probiotic Supplementation During Human Pregnancy Affects the Gut Microbiota and Immune Status |
| title_fullStr | Probiotic Supplementation During Human Pregnancy Affects the Gut Microbiota and Immune Status |
| title_full_unstemmed | Probiotic Supplementation During Human Pregnancy Affects the Gut Microbiota and Immune Status |
| title_short | Probiotic Supplementation During Human Pregnancy Affects the Gut Microbiota and Immune Status |
| title_sort | probiotic supplementation during human pregnancy affects the gut microbiota and immune status |
| topic | pregnancy probiotics immunomodulation machine learning interaction network |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2019.00254/full |
| work_keys_str_mv | AT yuyichen probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT zheli probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT kiandengtye probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT huijuanluo probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT xiaomeitang probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT yuliao probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT dongjuwang probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT juanzhou probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT pingyang probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT yimili probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT yingbingsu probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus AT xiaominxiao probioticsupplementationduringhumanpregnancyaffectsthegutmicrobiotaandimmunestatus |