Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells

Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells

Abstract Background Aberrant hedgehog (HH) signaling is implicated in the development of various cancer entities such as medulloblastoma. Activation of GLI transcription factors was revealed as the driving force upon pathway activation. Increased phosphorylation of essential effectors such as Smooth...

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Bibliographic Details
Main Authors: Tamara Scheidt, Oliver Alka, Humberto Gonczarowska-Jorge, Wolfgang Gruber, Florian Rathje, Margherita Dell’Aica, Marc Rurik, Oliver Kohlbacher, René P. Zahedi, Fritz Aberger, Christian G. Huber
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cell Communication and Signaling
Subjects:
Oncogenic signaling
Hedgehog signaling
Phosphorylation
Phosphoproteomics
Medulloblastoma
Kinases
Online Access:http://link.springer.com/article/10.1186/s12964-020-00591-0

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