A young lady with ANA negative SLE and Secondary Antip Phospholipid Syndrome
A B S T R A C T Systemic lupus erythematosus (SLE) is a chronic, inflammatory, autoimmune, multisystem connective multi system connective tissue disease characterized by various autoantibodies to nuclear and cytoplasmic antigens and commonly affects the joints and a variety of organs due to an over...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Indonesia Rheumatology Association
2021-02-01
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| Series: | Indonesian Journal of Rheumatology |
| Online Access: | https://journalrheumatology.or.id/index.php/ijr/article/view/154 |
| _version_ | 1818410371022585856 |
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| author | Richmond Ronald Gomes Deepankar Kumar Basak Kaniz Fatema Md. Rashidul Hasan |
| author_facet | Richmond Ronald Gomes Deepankar Kumar Basak Kaniz Fatema Md. Rashidul Hasan |
| author_sort | Richmond Ronald Gomes |
| collection | DOAJ |
| description | A B S T R A C T
Systemic lupus erythematosus (SLE) is a chronic, inflammatory,
autoimmune, multisystem connective multi system connective tissue
disease characterized by various autoantibodies to nuclear and cytoplasmic
antigens and commonly affects the joints and a variety of organs due to an
over activation of the body's immune system. There is wide heterogeneity in
presentation of SLE patients, including lung, central nervous system, skin,
kidney, and hematologic manifestations. The presence of antinuclear
antibodies (ANA) in serum is generally considered a decisive diagnostic sign
of SLE. However, a small subset of SLE patients who had the typical clinical
features of SLE was reported to show persistently negative ANA tests. Our
report describes a 24-yr-old female who presented with the clinical
manifestations of SLE such as malar rash, photosensitivity, arthritis, oral
ulcer, and proteinuria. The serum autoantibodies were all negative except
anti ribosomal P. She was also positive for lupus anticoagulantanti -
coagulant. She was treated with oral prednisolone , hydroxychloroquine
with topical tacrolimus, and improved significantly. Three months after,
repeat ANA, and anti-ds DNA showed persistent negativity, but lupus anti -
coagulant remained positive. This case suggests that ANA may not be
required in the pathogenesis of SLE. |
| first_indexed | 2024-12-14T10:14:27Z |
| format | Article |
| id | doaj.art-274f58321b1c44c2b238d01975d51408 |
| institution | Directory Open Access Journal |
| issn | 2086-1435 2581-1142 |
| language | English |
| last_indexed | 2024-12-14T10:14:27Z |
| publishDate | 2021-02-01 |
| publisher | Indonesia Rheumatology Association |
| record_format | Article |
| series | Indonesian Journal of Rheumatology |
| spelling | doaj.art-274f58321b1c44c2b238d01975d514082022-12-21T23:06:54ZengIndonesia Rheumatology AssociationIndonesian Journal of Rheumatology2086-14352581-11422021-02-0112232733210.37275/ijr.v12i2.154154A young lady with ANA negative SLE and Secondary Antip Phospholipid SyndromeRichmond Ronald Gomes0Deepankar Kumar Basak1Kaniz Fatema2Md. Rashidul Hasan3Associate Professor of Medicine, Ad-din Women’s Medical College and Hospital, Dhaka Associate Consultant, Medicine, Square Hospitals LimitedAssistant Professor of Dermatology, Ad-din Women’s Medical College and Hospital, Dhaka Associate Professor of Dermatology, US Bangla Medical College and Hospital, NarayangonjA B S T R A C T Systemic lupus erythematosus (SLE) is a chronic, inflammatory, autoimmune, multisystem connective multi system connective tissue disease characterized by various autoantibodies to nuclear and cytoplasmic antigens and commonly affects the joints and a variety of organs due to an over activation of the body's immune system. There is wide heterogeneity in presentation of SLE patients, including lung, central nervous system, skin, kidney, and hematologic manifestations. The presence of antinuclear antibodies (ANA) in serum is generally considered a decisive diagnostic sign of SLE. However, a small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative ANA tests. Our report describes a 24-yr-old female who presented with the clinical manifestations of SLE such as malar rash, photosensitivity, arthritis, oral ulcer, and proteinuria. The serum autoantibodies were all negative except anti ribosomal P. She was also positive for lupus anticoagulantanti - coagulant. She was treated with oral prednisolone , hydroxychloroquine with topical tacrolimus, and improved significantly. Three months after, repeat ANA, and anti-ds DNA showed persistent negativity, but lupus anti - coagulant remained positive. This case suggests that ANA may not be required in the pathogenesis of SLE.https://journalrheumatology.or.id/index.php/ijr/article/view/154 |
| spellingShingle | Richmond Ronald Gomes Deepankar Kumar Basak Kaniz Fatema Md. Rashidul Hasan A young lady with ANA negative SLE and Secondary Antip Phospholipid Syndrome Indonesian Journal of Rheumatology |
| title | A young lady with ANA negative SLE and Secondary Antip Phospholipid Syndrome |
| title_full | A young lady with ANA negative SLE and Secondary Antip Phospholipid Syndrome |
| title_fullStr | A young lady with ANA negative SLE and Secondary Antip Phospholipid Syndrome |
| title_full_unstemmed | A young lady with ANA negative SLE and Secondary Antip Phospholipid Syndrome |
| title_short | A young lady with ANA negative SLE and Secondary Antip Phospholipid Syndrome |
| title_sort | young lady with ana negative sle and secondary antip phospholipid syndrome |
| url | https://journalrheumatology.or.id/index.php/ijr/article/view/154 |
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