Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa
Clotiapine is an atypical antipsychotic indicated for the management of a series of acute psychotic disorders. The current literature lacks evidence concerning the tolerability and clinical use of this drug in the management of individuals with anorexia nervosa (AN). In this study, we report two cas...
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MDPI AG
2021-12-01
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| Series: | Behavioral Sciences |
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| Online Access: | https://www.mdpi.com/2076-328X/11/12/173 |
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| author | Jacopo Pruccoli Giulia Joy Leone Cristina Di Sarno Luigi Vetri Giuseppe Quatrosi Michele Roccella Antonia Parmeggiani |
| author_facet | Jacopo Pruccoli Giulia Joy Leone Cristina Di Sarno Luigi Vetri Giuseppe Quatrosi Michele Roccella Antonia Parmeggiani |
| author_sort | Jacopo Pruccoli |
| collection | DOAJ |
| description | Clotiapine is an atypical antipsychotic indicated for the management of a series of acute psychotic disorders. The current literature lacks evidence concerning the tolerability and clinical use of this drug in the management of individuals with anorexia nervosa (AN). In this study, we report two cases of adolescents with AN, treated with clotiapine. The reason for the administration of clotiapine was, for both patients, the manifestation of bizarre delusions concerning food and calories. Patient 1 presented a presyncope after the first dose of clotiapine, and treatment was rapidly discontinued. Patient 2 was treated with clotiapine for 9 months; doses were titrated from 20 mg/day to 70 mg/day, with an improvement in the reported delusions, which also enhanced compliance with psychological and nutritional interventions. EKG, QTc, white blood count, and red blood count were not relevantly influenced by the introduction of clotiapine in either patient. No extrapyramidal effect was documented. These reports stress the need for further studies assessing the tolerability and potential effect of clotiapine in treating adolescents with AN and delusional symptomatology. |
| first_indexed | 2024-03-10T04:34:27Z |
| format | Article |
| id | doaj.art-274f5da0da554e05bbf7c2cb63dd34f1 |
| institution | Directory Open Access Journal |
| issn | 2076-328X |
| language | English |
| last_indexed | 2024-03-10T04:34:27Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Behavioral Sciences |
| spelling | doaj.art-274f5da0da554e05bbf7c2cb63dd34f12023-11-23T03:51:38ZengMDPI AGBehavioral Sciences2076-328X2021-12-01111217310.3390/bs11120173Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia NervosaJacopo Pruccoli0Giulia Joy Leone1Cristina Di Sarno2Luigi Vetri3Giuseppe Quatrosi4Michele Roccella5Antonia Parmeggiani6IRCCS Istituto delle Scienze Neurologiche di Bologna, Centro Regionale per i Disturbi della Nutrizione e dell’Alimentazione in Età Evolutiva, U.O. di Neuropsichiatria dell’Età Pediatrica, 40138 Bologna, ItalyIRCCS Istituto delle Scienze Neurologiche di Bologna, Centro Regionale per i Disturbi della Nutrizione e dell’Alimentazione in Età Evolutiva, U.O. di Neuropsichiatria dell’Età Pediatrica, 40138 Bologna, ItalyIRCCS Istituto delle Scienze Neurologiche di Bologna, Centro Regionale per i Disturbi della Nutrizione e dell’Alimentazione in Età Evolutiva, U.O. di Neuropsichiatria dell’Età Pediatrica, 40138 Bologna, ItalyOasi Research Institute-IRCCS, 94018 Troina, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PromISE), University of Palermo, 90128 Palermo, ItalyDepartment of Psychology, Educational Science and Human Movement, University of Palermo, 90128 Palermo, ItalyIRCCS Istituto delle Scienze Neurologiche di Bologna, Centro Regionale per i Disturbi della Nutrizione e dell’Alimentazione in Età Evolutiva, U.O. di Neuropsichiatria dell’Età Pediatrica, 40138 Bologna, ItalyClotiapine is an atypical antipsychotic indicated for the management of a series of acute psychotic disorders. The current literature lacks evidence concerning the tolerability and clinical use of this drug in the management of individuals with anorexia nervosa (AN). In this study, we report two cases of adolescents with AN, treated with clotiapine. The reason for the administration of clotiapine was, for both patients, the manifestation of bizarre delusions concerning food and calories. Patient 1 presented a presyncope after the first dose of clotiapine, and treatment was rapidly discontinued. Patient 2 was treated with clotiapine for 9 months; doses were titrated from 20 mg/day to 70 mg/day, with an improvement in the reported delusions, which also enhanced compliance with psychological and nutritional interventions. EKG, QTc, white blood count, and red blood count were not relevantly influenced by the introduction of clotiapine in either patient. No extrapyramidal effect was documented. These reports stress the need for further studies assessing the tolerability and potential effect of clotiapine in treating adolescents with AN and delusional symptomatology.https://www.mdpi.com/2076-328X/11/12/173clotiapineanorexia nervosaeating disordersadolescentsinpatient treatmentantipsychotics |
| spellingShingle | Jacopo Pruccoli Giulia Joy Leone Cristina Di Sarno Luigi Vetri Giuseppe Quatrosi Michele Roccella Antonia Parmeggiani Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa Behavioral Sciences clotiapine anorexia nervosa eating disorders adolescents inpatient treatment antipsychotics |
| title | Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa |
| title_full | Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa |
| title_fullStr | Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa |
| title_full_unstemmed | Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa |
| title_short | Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa |
| title_sort | adjunctive clotiapine for the management of delusions in two adolescents with anorexia nervosa |
| topic | clotiapine anorexia nervosa eating disorders adolescents inpatient treatment antipsychotics |
| url | https://www.mdpi.com/2076-328X/11/12/173 |
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