Epigenetic regulation in mammalian preimplantation embryo development
<p>Abstract</p> <p>Preimplantation embryo development involves four stages: fertilization, cell cleavage, morula and blastocyst formation. During these stages, maternal and zygotic epigenetic factors play crucial roles. The gene expression profile is changed dramatically, chromatin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2009-06-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/7/1/59 |
| _version_ | 1818772221370302464 |
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| author | Shi Lingjun Wu Ji |
| author_facet | Shi Lingjun Wu Ji |
| author_sort | Shi Lingjun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Preimplantation embryo development involves four stages: fertilization, cell cleavage, morula and blastocyst formation. During these stages, maternal and zygotic epigenetic factors play crucial roles. The gene expression profile is changed dramatically, chromatin is modified and core histone elements undergo significant changes. Each preimplantation embryo stage has its own characteristic epigenetic profile, consistent with the acquisition of the capacity to support development. Moreover, histone modifications such as methylation and acetylation as well as other epigenetic events can act as regulatory switches of gene transcription. Because the epigenetic profile is largely related to differentiation, epigenetic dysfunction can give rise to developmental abnormalities. Thus, epigenetic profiling of the embryo is of pivotal importance clinically. Given the importance of these aspects, this review will mainly focus on the epigenetic profile during preimplantation embryo development, as well as interactions between epigenetic and genetic regulation in these early developmental stages.</p> |
| first_indexed | 2024-12-18T10:05:54Z |
| format | Article |
| id | doaj.art-274f5ee2f7e749fc928916bb8cd3bd8a |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-18T10:05:54Z |
| publishDate | 2009-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-274f5ee2f7e749fc928916bb8cd3bd8a2022-12-21T21:11:33ZengBMCReproductive Biology and Endocrinology1477-78272009-06-01715910.1186/1477-7827-7-59Epigenetic regulation in mammalian preimplantation embryo developmentShi LingjunWu Ji<p>Abstract</p> <p>Preimplantation embryo development involves four stages: fertilization, cell cleavage, morula and blastocyst formation. During these stages, maternal and zygotic epigenetic factors play crucial roles. The gene expression profile is changed dramatically, chromatin is modified and core histone elements undergo significant changes. Each preimplantation embryo stage has its own characteristic epigenetic profile, consistent with the acquisition of the capacity to support development. Moreover, histone modifications such as methylation and acetylation as well as other epigenetic events can act as regulatory switches of gene transcription. Because the epigenetic profile is largely related to differentiation, epigenetic dysfunction can give rise to developmental abnormalities. Thus, epigenetic profiling of the embryo is of pivotal importance clinically. Given the importance of these aspects, this review will mainly focus on the epigenetic profile during preimplantation embryo development, as well as interactions between epigenetic and genetic regulation in these early developmental stages.</p>http://www.rbej.com/content/7/1/59 |
| spellingShingle | Shi Lingjun Wu Ji Epigenetic regulation in mammalian preimplantation embryo development Reproductive Biology and Endocrinology |
| title | Epigenetic regulation in mammalian preimplantation embryo development |
| title_full | Epigenetic regulation in mammalian preimplantation embryo development |
| title_fullStr | Epigenetic regulation in mammalian preimplantation embryo development |
| title_full_unstemmed | Epigenetic regulation in mammalian preimplantation embryo development |
| title_short | Epigenetic regulation in mammalian preimplantation embryo development |
| title_sort | epigenetic regulation in mammalian preimplantation embryo development |
| url | http://www.rbej.com/content/7/1/59 |
| work_keys_str_mv | AT shilingjun epigeneticregulationinmammalianpreimplantationembryodevelopment AT wuji epigeneticregulationinmammalianpreimplantationembryodevelopment |