Electrosynthesized Poly(<i>o</i>-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates
Dopamine (DA) is a neurotransmitter, and its levels in the human body are associated with serious diseases. The need for a suitable detection method in medical practice has encouraged the development of electrochemical sensors that take advantage of DA electroactivity. Molecularly imprinted polymers...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/9/10/280 |
| _version_ | 1797514915252011008 |
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| author | Rosanna Ciriello Martina Graziano Giuliana Bianco Antonio Guerrieri |
| author_facet | Rosanna Ciriello Martina Graziano Giuliana Bianco Antonio Guerrieri |
| author_sort | Rosanna Ciriello |
| collection | DOAJ |
| description | Dopamine (DA) is a neurotransmitter, and its levels in the human body are associated with serious diseases. The need for a suitable detection method in medical practice has encouraged the development of electrochemical sensors that take advantage of DA electroactivity. Molecularly imprinted polymers (MIPs) are biomimetic materials able to selectively recognize target analytes. A novel MIP sensor for DA is proposed here based on a thin film of poly(<i>o</i>-aminophenol) electrosynthesized on bare Pt. A fast and easy method for executing the procedure for MIP deposition has been developed based on mild experimental conditions that are able to prevent electrode fouling from DA oxidation products. The MIP exhibited a limit of detection of 0.65 μM, and appreciable reproducibility and stability. The high recognition capability of poly(<i>o</i>-aminophenol) towards DA allowed for the achievement of notable selectivity: ascorbic acid, uric acid, serotonin, and tyramine did not interfere with DA detection, even at higher concentrations. The proposed sensor was successfully applied for DA detection in urine samples, showing good recovery. |
| first_indexed | 2024-03-10T06:39:15Z |
| format | Article |
| id | doaj.art-2750fd1e201542669d12f49217e2e1a5 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-10T06:39:15Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-2750fd1e201542669d12f49217e2e1a52023-11-22T17:49:32ZengMDPI AGChemosensors2227-90402021-09-0191028010.3390/chemosensors9100280Electrosynthesized Poly(<i>o</i>-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt SubstratesRosanna Ciriello0Martina Graziano1Giuliana Bianco2Antonio Guerrieri3Dipartimento di Scienze, Università degli Studi della Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyDipartimento di Scienze, Università degli Studi della Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyDipartimento di Scienze, Università degli Studi della Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyDipartimento di Scienze, Università degli Studi della Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyDopamine (DA) is a neurotransmitter, and its levels in the human body are associated with serious diseases. The need for a suitable detection method in medical practice has encouraged the development of electrochemical sensors that take advantage of DA electroactivity. Molecularly imprinted polymers (MIPs) are biomimetic materials able to selectively recognize target analytes. A novel MIP sensor for DA is proposed here based on a thin film of poly(<i>o</i>-aminophenol) electrosynthesized on bare Pt. A fast and easy method for executing the procedure for MIP deposition has been developed based on mild experimental conditions that are able to prevent electrode fouling from DA oxidation products. The MIP exhibited a limit of detection of 0.65 μM, and appreciable reproducibility and stability. The high recognition capability of poly(<i>o</i>-aminophenol) towards DA allowed for the achievement of notable selectivity: ascorbic acid, uric acid, serotonin, and tyramine did not interfere with DA detection, even at higher concentrations. The proposed sensor was successfully applied for DA detection in urine samples, showing good recovery.https://www.mdpi.com/2227-9040/9/10/280dopamineelectrochemical sensormolecularly imprinted polymerspoly(<i>o</i>-aminophenol)Pt electrodeurine |
| spellingShingle | Rosanna Ciriello Martina Graziano Giuliana Bianco Antonio Guerrieri Electrosynthesized Poly(<i>o</i>-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates Chemosensors dopamine electrochemical sensor molecularly imprinted polymers poly(<i>o</i>-aminophenol) Pt electrode urine |
| title | Electrosynthesized Poly(<i>o</i>-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates |
| title_full | Electrosynthesized Poly(<i>o</i>-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates |
| title_fullStr | Electrosynthesized Poly(<i>o</i>-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates |
| title_full_unstemmed | Electrosynthesized Poly(<i>o</i>-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates |
| title_short | Electrosynthesized Poly(<i>o</i>-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates |
| title_sort | electrosynthesized poly i o i aminophenol films as biomimetic coatings for dopamine detection on pt substrates |
| topic | dopamine electrochemical sensor molecularly imprinted polymers poly(<i>o</i>-aminophenol) Pt electrode urine |
| url | https://www.mdpi.com/2227-9040/9/10/280 |
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