Ndufa6 regulates adipogenic differentiation via Scd1
Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discov...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
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| Series: | Adipocyte |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21623945.2021.2007590 |
| _version_ | 1819096344647696384 |
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| author | Jingwei Zhang Wei Wang Ninghan Feng Xuan Jiang Shenglong Zhu Yong Q Chen |
| author_facet | Jingwei Zhang Wei Wang Ninghan Feng Xuan Jiang Shenglong Zhu Yong Q Chen |
| author_sort | Jingwei Zhang |
| collection | DOAJ |
| description | Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discovered. Transcriptomics and lipidomics approaches were used to explore the functional genes regulating adipogenic differentiation and the potential mechanism in OP9 cells and adipose-derived stem cells. In this study, we found that NADH:ubiquinone oxidoreductase subunit A6 (Ndufa6) participates in the regulation of adipogenic differentiation. Furthermore, we show that the effect of Ndufa6 is mediated through stearoyl-CoA desaturase 1 (Scd1) and demonstrate the inhibitory effect of a SCD1 inhibitor on adipogenesis. Our study broadens the understanding of adipogenic differentiation and offers NDUFA6-SCD1 as a potential therapeutic target for the treatment of obesity. |
| first_indexed | 2024-12-21T23:57:42Z |
| format | Article |
| id | doaj.art-27511d5f6f60430598d7247d000273d7 |
| institution | Directory Open Access Journal |
| issn | 2162-3945 2162-397X |
| language | English |
| last_indexed | 2024-12-21T23:57:42Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Adipocyte |
| spelling | doaj.art-27511d5f6f60430598d7247d000273d72022-12-21T18:45:47ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2021-01-0110164665710.1080/21623945.2021.20075902007590Ndufa6 regulates adipogenic differentiation via Scd1Jingwei Zhang0Wei Wang1Ninghan Feng2Xuan Jiang3Shenglong Zhu4Yong Q Chen5Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityJiangnan UniversityWuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityObesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discovered. Transcriptomics and lipidomics approaches were used to explore the functional genes regulating adipogenic differentiation and the potential mechanism in OP9 cells and adipose-derived stem cells. In this study, we found that NADH:ubiquinone oxidoreductase subunit A6 (Ndufa6) participates in the regulation of adipogenic differentiation. Furthermore, we show that the effect of Ndufa6 is mediated through stearoyl-CoA desaturase 1 (Scd1) and demonstrate the inhibitory effect of a SCD1 inhibitor on adipogenesis. Our study broadens the understanding of adipogenic differentiation and offers NDUFA6-SCD1 as a potential therapeutic target for the treatment of obesity.http://dx.doi.org/10.1080/21623945.2021.2007590obesityadipogenic differentiationndufa6scd |
| spellingShingle | Jingwei Zhang Wei Wang Ninghan Feng Xuan Jiang Shenglong Zhu Yong Q Chen Ndufa6 regulates adipogenic differentiation via Scd1 Adipocyte obesity adipogenic differentiation ndufa6 scd |
| title | Ndufa6 regulates adipogenic differentiation via Scd1 |
| title_full | Ndufa6 regulates adipogenic differentiation via Scd1 |
| title_fullStr | Ndufa6 regulates adipogenic differentiation via Scd1 |
| title_full_unstemmed | Ndufa6 regulates adipogenic differentiation via Scd1 |
| title_short | Ndufa6 regulates adipogenic differentiation via Scd1 |
| title_sort | ndufa6 regulates adipogenic differentiation via scd1 |
| topic | obesity adipogenic differentiation ndufa6 scd |
| url | http://dx.doi.org/10.1080/21623945.2021.2007590 |
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