Zebrafish: An Emerging Model for Studying Macrophage Functions in Cancer
Zebrafish provide a convenient and unique model for studying human cancers, owing to the high similarity between zebrafish and human genomes, the availability of genetic manipulation technologies, and the availability of large numbers and transparency of zebrafish embryos. Many researchers have rece...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2023-05-01
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| Series: | BIO Integration |
| Subjects: | |
| Online Access: | https://www.ingentaconnect.com/contentone/cscript/bioi/2023/00000004/00000001/art00006 |
| _version_ | 1797826673649909760 |
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| author | Xiuting Guo Linjia Jiang |
| author_facet | Xiuting Guo Linjia Jiang |
| author_sort | Xiuting Guo |
| collection | DOAJ |
| description | Zebrafish provide a convenient and unique model for studying human cancers, owing to the high similarity between zebrafish and human genomes, the availability of genetic manipulation technologies, and the availability of large numbers and transparency of zebrafish embryos. Many researchers have recently used zebrafish cancer models to examine the functions of macrophages in tumorigenesis, tumor growth and metastasis. Here, we present evidence that zebrafish cancer cells produce signals that are conserved with respect to those in humans and lead to the recruitment of heterogeneously activated macrophages in response to specific tumor types and tumorigenic stages, thereby promoting cancer initiation and progression. We also summarize how cancer cells interact with macrophages, emphasizing live imaging studies for visualization of dynamic material interchange. |
| first_indexed | 2024-04-09T12:36:10Z |
| format | Article |
| id | doaj.art-275281277cd14f53a424668b121c9184 |
| institution | Directory Open Access Journal |
| issn | 2712-0082 |
| language | English |
| last_indexed | 2024-04-09T12:36:10Z |
| publishDate | 2023-05-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | BIO Integration |
| spelling | doaj.art-275281277cd14f53a424668b121c91842023-05-15T09:42:08ZengCompuscript LtdBIO Integration2712-00822023-05-0141384410.15212/bioi-2022-0023Zebrafish: An Emerging Model for Studying Macrophage Functions in CancerXiuting Guo0Linjia Jiang1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaZebrafish provide a convenient and unique model for studying human cancers, owing to the high similarity between zebrafish and human genomes, the availability of genetic manipulation technologies, and the availability of large numbers and transparency of zebrafish embryos. Many researchers have recently used zebrafish cancer models to examine the functions of macrophages in tumorigenesis, tumor growth and metastasis. Here, we present evidence that zebrafish cancer cells produce signals that are conserved with respect to those in humans and lead to the recruitment of heterogeneously activated macrophages in response to specific tumor types and tumorigenic stages, thereby promoting cancer initiation and progression. We also summarize how cancer cells interact with macrophages, emphasizing live imaging studies for visualization of dynamic material interchange.https://www.ingentaconnect.com/contentone/cscript/bioi/2023/00000004/00000001/art00006zebrafishcancermacrophagerecruitmentactivation |
| spellingShingle | Xiuting Guo Linjia Jiang Zebrafish: An Emerging Model for Studying Macrophage Functions in Cancer BIO Integration zebrafish cancer macrophage recruitment activation |
| title | Zebrafish: An Emerging Model for Studying Macrophage Functions in Cancer |
| title_full | Zebrafish: An Emerging Model for Studying Macrophage Functions in Cancer |
| title_fullStr | Zebrafish: An Emerging Model for Studying Macrophage Functions in Cancer |
| title_full_unstemmed | Zebrafish: An Emerging Model for Studying Macrophage Functions in Cancer |
| title_short | Zebrafish: An Emerging Model for Studying Macrophage Functions in Cancer |
| title_sort | zebrafish an emerging model for studying macrophage functions in cancer |
| topic | zebrafish cancer macrophage recruitment activation |
| url | https://www.ingentaconnect.com/contentone/cscript/bioi/2023/00000004/00000001/art00006 |
| work_keys_str_mv | AT xiutingguo zebrafishanemergingmodelforstudyingmacrophagefunctionsincancer AT linjiajiang zebrafishanemergingmodelforstudyingmacrophagefunctionsincancer |