Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature
A lack of effective treatment for patients with treatment-resistant depression (TRD) has led to the evaluation of ketamine, an N-methyl- D-aspartate receptor antagonist. Despite the demonstrated short-term benefits of using intravenous (IV) ketamine, side effects and the difficulty in administering...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2016-07-01
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| Series: | International Journal of Medical Students |
| Subjects: | |
| Online Access: | http://ijms.info/IJMS/article/view/153 |
| _version_ | 1827853955958308864 |
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| author | Patrick Arthur Twohig Vaughn Huckfeldt |
| author_facet | Patrick Arthur Twohig Vaughn Huckfeldt |
| author_sort | Patrick Arthur Twohig |
| collection | DOAJ |
| description | A lack of effective treatment for patients with treatment-resistant depression (TRD) has led to the evaluation of ketamine, an N-methyl- D-aspartate receptor antagonist. Despite the demonstrated short-term benefits of using intravenous (IV) ketamine, side effects and the difficulty in administering ketamine outside the health-care setting has raised interest in alternative dosage forms. Research articles evaluating oral or intranasal (IN) ketamine were retrieved from the PubMed database. Patients who received oral or IN ketamine experienced a similar reduction in depressive symptoms within 24 hours of treatment and fewer side effects compared to patients who received IV ketamine. Novel administration forms of ketamine provide an opportunity for patients with TRD to achieve remission with fewer adverse side effects. Future studies should continue to evaluate these administration strategies in the hope of promoting ketamine’s use outside health-care settings and for longer time periods. |
| first_indexed | 2024-03-12T11:14:23Z |
| format | Article |
| id | doaj.art-27546f51c60547faa4f554c46d4f2fe3 |
| institution | Directory Open Access Journal |
| issn | 2076-6327 |
| language | English |
| last_indexed | 2024-03-12T11:14:23Z |
| publishDate | 2016-07-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | International Journal of Medical Students |
| spelling | doaj.art-27546f51c60547faa4f554c46d4f2fe32023-09-02T02:19:36ZengUniversity Library System, University of PittsburghInternational Journal of Medical Students2076-63272016-07-0142647110.5195/ijms.2016.153153Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the LiteraturePatrick Arthur Twohig0Vaughn Huckfeldt1Saba University School of Medicine, Caribbean Netherlands.Saba University School of Medicine, Caribbean Netherlands.A lack of effective treatment for patients with treatment-resistant depression (TRD) has led to the evaluation of ketamine, an N-methyl- D-aspartate receptor antagonist. Despite the demonstrated short-term benefits of using intravenous (IV) ketamine, side effects and the difficulty in administering ketamine outside the health-care setting has raised interest in alternative dosage forms. Research articles evaluating oral or intranasal (IN) ketamine were retrieved from the PubMed database. Patients who received oral or IN ketamine experienced a similar reduction in depressive symptoms within 24 hours of treatment and fewer side effects compared to patients who received IV ketamine. Novel administration forms of ketamine provide an opportunity for patients with TRD to achieve remission with fewer adverse side effects. Future studies should continue to evaluate these administration strategies in the hope of promoting ketamine’s use outside health-care settings and for longer time periods.http://ijms.info/IJMS/article/view/153ketaminedepressive disordertreatment-resistantadministrationoraladministration, intranasalintravenous |
| spellingShingle | Patrick Arthur Twohig Vaughn Huckfeldt Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature International Journal of Medical Students ketamine depressive disorder treatment-resistant administration oral administration, intranasal intravenous |
| title | Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature |
| title_full | Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature |
| title_fullStr | Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature |
| title_full_unstemmed | Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature |
| title_short | Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature |
| title_sort | using oral and intranasal dosage forms of ketamine for managing treatment resistant depression a review of the literature |
| topic | ketamine depressive disorder treatment-resistant administration oral administration, intranasal intravenous |
| url | http://ijms.info/IJMS/article/view/153 |
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