Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease
Objective Recent reports of hearing impairment in Parkinson’s disease (PD) have suggested that auditory dysfunction could be a non-motor manifestation of PD. These reports were based on observations of elderly patients for whom presbycusis may, to some extent, have contributed to hearing dysfunction...
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2019-05-01
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| Series: | Journal of Movement Disorders |
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| Online Access: | http://www.e-jmd.org/upload/jmd-18048.pdf |
| _version_ | 1797716034980937728 |
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| author | Kuldeep Shetty Syam Krishnan Jissa Vinoda Thulaseedharan Manju Mohan Asha Kishore |
| author_facet | Kuldeep Shetty Syam Krishnan Jissa Vinoda Thulaseedharan Manju Mohan Asha Kishore |
| author_sort | Kuldeep Shetty |
| collection | DOAJ |
| description | Objective Recent reports of hearing impairment in Parkinson’s disease (PD) have suggested that auditory dysfunction could be a non-motor manifestation of PD. These reports were based on observations of elderly patients for whom presbycusis may, to some extent, have contributed to hearing dysfunction. Therefore, we aimed to explore the auditory functions in younger patients with PD. Methods We conducted a case-control study in a relatively younger (< 55 years of age at study time) population of PD patients and healthy volunteers to test whether auditory dysfunction is a significant non-motor dysfunction in PD. Pure tone audiometry (PTA) and brainstem evoked response audiometry (BERA) were performed in all participants. Results None of the patients or controls reported hearing deficits. Fifty-one patients with PD and 50 healthy volunteers who were age- and gender-matched to the patients participated. PTA-detected hearing impairment was found in 64.7% of patients and 28% of controls (p < 0.001) for both low-mid and/or high frequencies. Hearing impairment was more frequent in the younger subgroups of patients than age-matched controls, while the frequency of hearing impairment was similar in older groups of subjects. BERA was not different between patients and controls. Conclusion Asymptomatic auditory dysfunction is a common non-motor manifestation of early-onset PD and more frequent in younger patients, indicating that it may be independent of aging. The mechanism underlying this dysfunction appears to be peripheral, although a central dysfunction cannot be ruled out based on the findings of this study. |
| first_indexed | 2024-03-12T08:15:35Z |
| format | Article |
| id | doaj.art-2758a1e8bc634257b785b53aa3753dbe |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T08:15:35Z |
| publishDate | 2019-05-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-2758a1e8bc634257b785b53aa3753dbe2023-09-02T18:53:33ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392019-05-01122849010.14802/jmd.18048241Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s DiseaseKuldeep Shetty0Syam Krishnan1Jissa Vinoda Thulaseedharan2Manju Mohan3Asha Kishore4 Comprehensive Care Centre for Movement Disorders, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India Comprehensive Care Centre for Movement Disorders, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India Department of Audiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India Comprehensive Care Centre for Movement Disorders, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, IndiaObjective Recent reports of hearing impairment in Parkinson’s disease (PD) have suggested that auditory dysfunction could be a non-motor manifestation of PD. These reports were based on observations of elderly patients for whom presbycusis may, to some extent, have contributed to hearing dysfunction. Therefore, we aimed to explore the auditory functions in younger patients with PD. Methods We conducted a case-control study in a relatively younger (< 55 years of age at study time) population of PD patients and healthy volunteers to test whether auditory dysfunction is a significant non-motor dysfunction in PD. Pure tone audiometry (PTA) and brainstem evoked response audiometry (BERA) were performed in all participants. Results None of the patients or controls reported hearing deficits. Fifty-one patients with PD and 50 healthy volunteers who were age- and gender-matched to the patients participated. PTA-detected hearing impairment was found in 64.7% of patients and 28% of controls (p < 0.001) for both low-mid and/or high frequencies. Hearing impairment was more frequent in the younger subgroups of patients than age-matched controls, while the frequency of hearing impairment was similar in older groups of subjects. BERA was not different between patients and controls. Conclusion Asymptomatic auditory dysfunction is a common non-motor manifestation of early-onset PD and more frequent in younger patients, indicating that it may be independent of aging. The mechanism underlying this dysfunction appears to be peripheral, although a central dysfunction cannot be ruled out based on the findings of this study.http://www.e-jmd.org/upload/jmd-18048.pdfParkinson’s diseasehearing impairmentnon-motor symptomspure tone audiometrybrainstem evoked response audiometry |
| spellingShingle | Kuldeep Shetty Syam Krishnan Jissa Vinoda Thulaseedharan Manju Mohan Asha Kishore Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease Journal of Movement Disorders Parkinson’s disease hearing impairment non-motor symptoms pure tone audiometry brainstem evoked response audiometry |
| title | Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease |
| title_full | Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease |
| title_fullStr | Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease |
| title_full_unstemmed | Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease |
| title_short | Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease |
| title_sort | asymptomatic hearing impairment frequently occurs in early onset parkinson s disease |
| topic | Parkinson’s disease hearing impairment non-motor symptoms pure tone audiometry brainstem evoked response audiometry |
| url | http://www.e-jmd.org/upload/jmd-18048.pdf |
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