The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation
Acute renal injury (AKI) is a complex clinical syndrome, involving a series of pathophysiological processes, in which inflammation plays a key role. Identification and verification of gene signatures associated with inflammatory onset and progression are imperative for understanding the molecular me...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.923239/full |
| _version_ | 1818554924319899648 |
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| author | Bojun Li Fangyou Lin Yuqi Xia Zehua Ye Xinzhou Yan Baofeng Song Tianhui Yuan Lei Li Xiangjun Zhou Weimin Yu Fan Cheng |
| author_facet | Bojun Li Fangyou Lin Yuqi Xia Zehua Ye Xinzhou Yan Baofeng Song Tianhui Yuan Lei Li Xiangjun Zhou Weimin Yu Fan Cheng |
| author_sort | Bojun Li |
| collection | DOAJ |
| description | Acute renal injury (AKI) is a complex clinical syndrome, involving a series of pathophysiological processes, in which inflammation plays a key role. Identification and verification of gene signatures associated with inflammatory onset and progression are imperative for understanding the molecular mechanisms involved in AKI pathogenesis. Non-coding RNAs (ncRNAs), involved in epigenetic modifications of inflammatory responses, are associated with the aberrant expression of inflammation-related genes in AKI. However, its regulatory role in gene expression involves precise transcriptional regulation mechanisms which have not been fully elucidated in the complex and volatile inflammatory response of AKI. In this study, we systematically review current research on the intrinsic molecular mechanisms of ncRNAs that regulate the inflammatory response in AKI. We aim to provide potential research directions and strategies for developing ncRNA-targeted gene therapies as an intervention for the inflammatory damage in AKI. |
| first_indexed | 2024-12-12T09:46:26Z |
| format | Article |
| id | doaj.art-275996b9a3be492294f0c9b738b9a8aa |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T09:46:26Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-275996b9a3be492294f0c9b738b9a8aa2022-12-22T00:28:23ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-06-011310.3389/fphys.2022.923239923239The Intersection of Acute Kidney Injury and Non-Coding RNAs: InflammationBojun LiFangyou LinYuqi XiaZehua YeXinzhou YanBaofeng SongTianhui YuanLei LiXiangjun ZhouWeimin YuFan ChengAcute renal injury (AKI) is a complex clinical syndrome, involving a series of pathophysiological processes, in which inflammation plays a key role. Identification and verification of gene signatures associated with inflammatory onset and progression are imperative for understanding the molecular mechanisms involved in AKI pathogenesis. Non-coding RNAs (ncRNAs), involved in epigenetic modifications of inflammatory responses, are associated with the aberrant expression of inflammation-related genes in AKI. However, its regulatory role in gene expression involves precise transcriptional regulation mechanisms which have not been fully elucidated in the complex and volatile inflammatory response of AKI. In this study, we systematically review current research on the intrinsic molecular mechanisms of ncRNAs that regulate the inflammatory response in AKI. We aim to provide potential research directions and strategies for developing ncRNA-targeted gene therapies as an intervention for the inflammatory damage in AKI.https://www.frontiersin.org/articles/10.3389/fphys.2022.923239/fullacute kidney injurynon-coding RNAinflammationNF-κB signaling pathwaysepsis |
| spellingShingle | Bojun Li Fangyou Lin Yuqi Xia Zehua Ye Xinzhou Yan Baofeng Song Tianhui Yuan Lei Li Xiangjun Zhou Weimin Yu Fan Cheng The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation Frontiers in Physiology acute kidney injury non-coding RNA inflammation NF-κB signaling pathway sepsis |
| title | The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation |
| title_full | The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation |
| title_fullStr | The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation |
| title_full_unstemmed | The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation |
| title_short | The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation |
| title_sort | intersection of acute kidney injury and non coding rnas inflammation |
| topic | acute kidney injury non-coding RNA inflammation NF-κB signaling pathway sepsis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.923239/full |
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