Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata
Aralia elata (Miq.) Seem. is a highly nutritious wild vegetable widely consumed in China, it can be made into salad, dumplings, pickles and soup for its fresh smell. In the phytochemical investigation of the constituents of Aralia elata, three new triterpene saponins (1–3), named congmusaponin I, II...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618301658 |
| _version_ | 1818415654778175488 |
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| author | Yan Zhang Wei Wang Huan He Xiao-yu Song Guo-dong Yao Shao-jiang Song |
| author_facet | Yan Zhang Wei Wang Huan He Xiao-yu Song Guo-dong Yao Shao-jiang Song |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Aralia elata (Miq.) Seem. is a highly nutritious wild vegetable widely consumed in China, it can be made into salad, dumplings, pickles and soup for its fresh smell. In the phytochemical investigation of the constituents of Aralia elata, three new triterpene saponins (1–3), named congmusaponin I, II and III, along with twelve known ones (4–15) were isolated from the 70% EtOH extract of buds. Their structures were determined on the basis of spectroscopic analyses. All isolates were investigated for their neuroprotective effect on H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y), and the new compound 1 showed significant protective activity at 50 or 100 μM. The possible mechanism of compound 1 was proved to be through inhibiting H2O2-induced apoptosis and fighting against oxidative stress in neurodegenerative disease. The current study suggests that triterpene saponins in Aralia elata may play an important role in the neuroprotective properties. |
| first_indexed | 2024-12-14T11:38:26Z |
| format | Article |
| id | doaj.art-275b92f52e6b4a4a95103a7eb18d25dc |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T11:38:26Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-275b92f52e6b4a4a95103a7eb18d25dc2022-12-21T23:02:54ZengElsevierJournal of Functional Foods1756-46462018-06-0145313320Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elataYan Zhang0Wei Wang1Huan He2Xiao-yu Song3Guo-dong Yao4Shao-jiang Song5School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaCorresponding author.; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaAralia elata (Miq.) Seem. is a highly nutritious wild vegetable widely consumed in China, it can be made into salad, dumplings, pickles and soup for its fresh smell. In the phytochemical investigation of the constituents of Aralia elata, three new triterpene saponins (1–3), named congmusaponin I, II and III, along with twelve known ones (4–15) were isolated from the 70% EtOH extract of buds. Their structures were determined on the basis of spectroscopic analyses. All isolates were investigated for their neuroprotective effect on H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y), and the new compound 1 showed significant protective activity at 50 or 100 μM. The possible mechanism of compound 1 was proved to be through inhibiting H2O2-induced apoptosis and fighting against oxidative stress in neurodegenerative disease. The current study suggests that triterpene saponins in Aralia elata may play an important role in the neuroprotective properties.http://www.sciencedirect.com/science/article/pii/S1756464618301658Aralia elataTriterpene saponinsNeuroprotectiveOxidative stress |
| spellingShingle | Yan Zhang Wei Wang Huan He Xiao-yu Song Guo-dong Yao Shao-jiang Song Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata Journal of Functional Foods Aralia elata Triterpene saponins Neuroprotective Oxidative stress |
| title | Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata |
| title_full | Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata |
| title_fullStr | Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata |
| title_full_unstemmed | Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata |
| title_short | Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata |
| title_sort | triterpene saponins with neuroprotective effects from a wild vegetable aralia elata |
| topic | Aralia elata Triterpene saponins Neuroprotective Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618301658 |
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