The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation
Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse signaling, wherein RANKL molecules on osteoblasts...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.648084/full |
| _version_ | 1819082148221550592 |
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| author | Fatma Rashed Fatma Rashed Shingo Kamijyo Yuri Shimizu Yuna Hirohashi Masud Khan Yasutaka Sugamori Ramachandran Murali Kazuhiro Aoki |
| author_facet | Fatma Rashed Fatma Rashed Shingo Kamijyo Yuri Shimizu Yuna Hirohashi Masud Khan Yasutaka Sugamori Ramachandran Murali Kazuhiro Aoki |
| author_sort | Fatma Rashed |
| collection | DOAJ |
| description | Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse signaling, wherein RANKL molecules on osteoblasts work as receptors to stimulate osteoblast differentiation. However, why RANKL-binding peptides stimulate osteoblast differentiation while osteoprotegerin (OPG), which is well known to bind to RANKL, cannot activate osteoblast differentiation has remained unclear. In this mini-review, we introduce three main issues: (1) The inhibitory effects of two RANKL-binding peptides (W9 and OP3-4) on bone resorption; (2) The stimulatory effects of the RANKL-binding peptides on osteoblast differentiation; and (3) The accumulation and membrane clustering of RANKL molecules at the cell surface of osteoblasts as a potential molecular switch stimulating osteoblast differentiation by RANKL-binding peptides. |
| first_indexed | 2024-12-21T20:12:04Z |
| format | Article |
| id | doaj.art-275c273d07f74135b4410f55198e6131 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T20:12:04Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-275c273d07f74135b4410f55198e61312022-12-21T18:51:43ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.648084648084The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone FormationFatma Rashed0Fatma Rashed1Shingo Kamijyo2Yuri Shimizu3Yuna Hirohashi4Masud Khan5Yasutaka Sugamori6Ramachandran Murali7Kazuhiro Aoki8Graduate School of Medical and Dental Sciences, Institute X, Department of Basic Oral Health Engineering, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Oral Biology, Faculty of Dentistry, Damanhour University, El Behera, EgyptGraduate School of Medical and Dental Sciences, Institute X, Department of Basic Oral Health Engineering, Tokyo Medical and Dental University, Tokyo, JapanGraduate School of Medical and Dental Sciences, Institute X, Department of Basic Oral Health Engineering, Tokyo Medical and Dental University, Tokyo, JapanGraduate School of Medical and Dental Sciences, Institute X, Department of Basic Oral Health Engineering, Tokyo Medical and Dental University, Tokyo, JapanGraduate School of Medical and Dental Sciences, Institute X, Department of Basic Oral Health Engineering, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Dentistry and Oral Surgery, Saitama Medical University, Saitama, JapanBiomedical Sciences, Research Division of Immunology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesGraduate School of Medical and Dental Sciences, Institute X, Department of Basic Oral Health Engineering, Tokyo Medical and Dental University, Tokyo, JapanReceptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse signaling, wherein RANKL molecules on osteoblasts work as receptors to stimulate osteoblast differentiation. However, why RANKL-binding peptides stimulate osteoblast differentiation while osteoprotegerin (OPG), which is well known to bind to RANKL, cannot activate osteoblast differentiation has remained unclear. In this mini-review, we introduce three main issues: (1) The inhibitory effects of two RANKL-binding peptides (W9 and OP3-4) on bone resorption; (2) The stimulatory effects of the RANKL-binding peptides on osteoblast differentiation; and (3) The accumulation and membrane clustering of RANKL molecules at the cell surface of osteoblasts as a potential molecular switch stimulating osteoblast differentiation by RANKL-binding peptides.https://www.frontiersin.org/articles/10.3389/fcell.2021.648084/fullRANKL-binding peptidebone resorptionbone formationRANKL-reverse signalingRANKL clusteringosteoprotegerin |
| spellingShingle | Fatma Rashed Fatma Rashed Shingo Kamijyo Yuri Shimizu Yuna Hirohashi Masud Khan Yasutaka Sugamori Ramachandran Murali Kazuhiro Aoki The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation Frontiers in Cell and Developmental Biology RANKL-binding peptide bone resorption bone formation RANKL-reverse signaling RANKL clustering osteoprotegerin |
| title | The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation |
| title_full | The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation |
| title_fullStr | The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation |
| title_full_unstemmed | The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation |
| title_short | The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation |
| title_sort | effects of receptor activator of nf κb ligand binding peptides on bone resorption and bone formation |
| topic | RANKL-binding peptide bone resorption bone formation RANKL-reverse signaling RANKL clustering osteoprotegerin |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.648084/full |
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