Long noncoding RNAs: new insights in modulating mammalian spermatogenesis
Abstract Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many m...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Journal of Animal Science and Biotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40104-019-0424-8 |
| _version_ | 1811286104761958400 |
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| author | Bahlibi Weldegebriall Sahlu Shanjiang Zhao Xiuge Wang Saqib Umer Huiying Zou Jinming Huang Huabin Zhu |
| author_facet | Bahlibi Weldegebriall Sahlu Shanjiang Zhao Xiuge Wang Saqib Umer Huiying Zou Jinming Huang Huabin Zhu |
| author_sort | Bahlibi Weldegebriall Sahlu |
| collection | DOAJ |
| description | Abstract Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs (lncRNAs) and highly regulated and specific gene expression. LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored. Only a few of them have post-meiotic; however, lncRNAs are involved in many cellular biological processes. The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies. This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis. |
| first_indexed | 2024-04-13T02:54:47Z |
| format | Article |
| id | doaj.art-275c9ba4c04645be93bde4310deef80a |
| institution | Directory Open Access Journal |
| issn | 2049-1891 |
| language | English |
| last_indexed | 2024-04-13T02:54:47Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Animal Science and Biotechnology |
| spelling | doaj.art-275c9ba4c04645be93bde4310deef80a2022-12-22T03:05:43ZengBMCJournal of Animal Science and Biotechnology2049-18912020-02-0111111210.1186/s40104-019-0424-8Long noncoding RNAs: new insights in modulating mammalian spermatogenesisBahlibi Weldegebriall Sahlu0Shanjiang Zhao1Xiuge Wang2Saqib Umer3Huiying Zou4Jinming Huang5Huabin Zhu6Embryo Biotechnology and Reproduction Laboratory, Institute of Animal Science, Chinese Academy of Agricultural SciencesEmbryo Biotechnology and Reproduction Laboratory, Institute of Animal Science, Chinese Academy of Agricultural SciencesDairy Cattle Research Center, Shandong Academy of Agricultural SciencesEmbryo Biotechnology and Reproduction Laboratory, Institute of Animal Science, Chinese Academy of Agricultural SciencesEmbryo Biotechnology and Reproduction Laboratory, Institute of Animal Science, Chinese Academy of Agricultural SciencesDairy Cattle Research Center, Shandong Academy of Agricultural SciencesEmbryo Biotechnology and Reproduction Laboratory, Institute of Animal Science, Chinese Academy of Agricultural SciencesAbstract Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs (lncRNAs) and highly regulated and specific gene expression. LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored. Only a few of them have post-meiotic; however, lncRNAs are involved in many cellular biological processes. The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies. This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis.http://link.springer.com/article/10.1186/s40104-019-0424-8Germ cellLong noncoding RNAMammalian spermatogenesisRegulatory pathwaysSpermatocytes |
| spellingShingle | Bahlibi Weldegebriall Sahlu Shanjiang Zhao Xiuge Wang Saqib Umer Huiying Zou Jinming Huang Huabin Zhu Long noncoding RNAs: new insights in modulating mammalian spermatogenesis Journal of Animal Science and Biotechnology Germ cell Long noncoding RNA Mammalian spermatogenesis Regulatory pathways Spermatocytes |
| title | Long noncoding RNAs: new insights in modulating mammalian spermatogenesis |
| title_full | Long noncoding RNAs: new insights in modulating mammalian spermatogenesis |
| title_fullStr | Long noncoding RNAs: new insights in modulating mammalian spermatogenesis |
| title_full_unstemmed | Long noncoding RNAs: new insights in modulating mammalian spermatogenesis |
| title_short | Long noncoding RNAs: new insights in modulating mammalian spermatogenesis |
| title_sort | long noncoding rnas new insights in modulating mammalian spermatogenesis |
| topic | Germ cell Long noncoding RNA Mammalian spermatogenesis Regulatory pathways Spermatocytes |
| url | http://link.springer.com/article/10.1186/s40104-019-0424-8 |
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