Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1

Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1

The human 8-oxoguanine DNA glycosylase OGG1 is involved in base excision repair (BER), one of several DNA repair mechanisms that may counteract the effects of chemo- and radiation therapy for the treatment of cancer. We envisage that potent inhibitors of OGG1 may be found among the 9-alkyl-8-oxoguan...

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Bibliographic Details
Main Authors: Tushar R. Mahajan, Mari Eknes Ytre-Arne, Pernille Strøm-Andersen, Bjørn Dalhus, Lise-Lotte Gundersen
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Molecules
Subjects:
alkylation
cancer
DNA
enzyme inhibitors
guanine
halogenation
Online Access:http://www.mdpi.com/1420-3049/20/9/15944

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